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Published on: February 10, 2015
Are changes in expression of actin genes involved in estrogen-induced cholestasis?
1Facultad de Medicina, Universidad Juárez del Estado de Durango, Department of Biochemistry, México.
Abstract:
It is postulated that cholestasis associated with high estrogen levels found in women in various conditions, is due to alterations in structure and/or function of the system of actin microfilaments by estrogen-induced changes on expression of actin genes and/or some regulatory actin-binding protein genes. Because bile secretion by hepatocytes is apparently mediated by the microfilamentous system of actin, the proposed hormonally induced dysfunction of this system could be translated to cholestasis.

