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Related Concept Videos

Stroke: Introduction and Types01:29

Stroke: Introduction and Types

A stroke is an acute neurological event caused by the sudden disruption of cerebral blood flow, leading to rapid loss of neuronal function. Neurons depend on continuous oxygen and glucose supply, so even brief interruptions can cause irreversible injury within minutes. Strokes are classified into ischemic and hemorrhagic types.Ischemic StrokeIschemic strokes are most common and occur due to arterial occlusion, depriving brain tissue of oxygen and nutrients. This leads to energy failure, ionic...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Transient Ischemic Attack l: Introduction01:26

Transient Ischemic Attack l: Introduction

A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...

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Related Experiment Video

Updated: May 29, 2026

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

A stroke -- or something else?

Hillary R Mount1, Jeffrey D Schlaudecker

  • 1The Christ Hospital/University of Cincinnati, Family Medicine Residency Program, Cincinnati, OH, USA. hillary.mount@thechristhospital.com

The Journal of Family Practice
|September 9, 2011
PubMed
Summary
This summary is machine-generated.

A patient with a history of stroke experienced leg weakness and gait imbalance. Further investigation was needed as initial tests were inconclusive.

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Permanent Cerebral Vessel Occlusion via Double Ligature and Transection
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Permanent Cerebral Vessel Occlusion via Double Ligature and Transection

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A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
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Permanent Cerebral Vessel Occlusion via Double Ligature and Transection

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Area of Science:

  • Neurology
  • Geriatric Medicine

Background:

  • A patient with a prior Cerebrovascular Accident (CVA) presented with new neurological symptoms.
  • Recurrent or progressive neurological deficits following a CVA require thorough investigation.

Observation:

  • The patient reported progressive numbness and weakness in the right leg and foot.
  • An increasingly unsteady gait was noted, impacting mobility and fall risk.

Findings:

  • Initial laboratory workup did not reveal an identifiable cause for the patient's symptoms.
  • The clinical presentation suggested a potential neurological or musculoskeletal issue requiring further diagnostic evaluation.

Implications:

  • Prompt and accurate diagnosis is crucial for managing patients with post-CVA complications.
  • Understanding the etiology of new-onset focal neurological deficits is essential for effective treatment planning.