Related Experiment Video
Updated: May 29, 2026
05:10
Improved Methodology for Studying Postnatal Osteogenesis via Intramembranous Ossification in a Murine Bone Marrow Injury Model
Published on: February 7, 2025
Bone marrow lesions: a universal bone response to injury?
Erik Fink Eriksen1, Johan Diederich Ringe
1Department of Endocrinology, Oslo University Hospital, P.O. Box 4956 Nydalen, 0424 Oslo, Norway. e.f.eriksen@medisin.uio
Rheumatology International
|September 9, 2011
Summary
Bone marrow lesions (BMLs), identified via MRI, are linked to various musculoskeletal diseases and pain. This review explores their features and potential treatments, including antiresorptive drugs.
Area of Science:
- Radiology
- Rheumatology
- Pathology
Background:
- Magnetic resonance imaging (MRI) has revealed bone marrow lesions (BMLs) as a significant finding in musculoskeletal disorders.
- BMLs, characterized by increased water signal in bone marrow, are associated with numerous inflammatory and non-inflammatory rheumatologic conditions.
- These lesions are implicated in patient pain and can negatively impact prognosis.
Purpose of the Study:
- To review current knowledge on BMLs, focusing on clinical and histological aspects in various diseases.
- To propose a unifying hypothesis for BMLs based on imaging characteristics.
- To correlate this hypothesis with the efficacy of treatments, particularly bone antiresorptive drugs.
Main Methods:
- Literature review of studies on bone marrow lesions.
- Analysis of clinical and histological features of BMLs in inflammatory and non-inflammatory conditions.
- Evaluation of imaging appearances and treatment outcomes.
Main Results:
- BMLs are a common finding in rheumatologic diseases, contributing to pain and poorer outcomes.
- A unifying hypothesis linking imaging findings to disease processes is presented.
- Bone antiresorptive drugs show potential benefits in managing BML-associated symptoms.
Conclusions:
- BMLs are a crucial diagnostic and prognostic indicator in musculoskeletal and rheumatologic diseases.
- Understanding BMLs through imaging and histology aids in disease management.
- Further research into treatments, including antiresorptive agents, is warranted for BMLs.
More Related Videos
Related Concept Videos
01:27Fractures: Bone Repair
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
01:29Blood and Nerve Supply to the Bones
Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
01:22Bone Marrow Sampling and Transplants
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
01:40Bone Remodeling
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
01:30Bone Cells and Tissue
Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the periosteum and...
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the periosteum and...
01:23Bone as Supporting Connective Tissue
Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts— that give the...
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts— that give the...