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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...

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Related Experiment Video

Updated: May 29, 2026

Trabecular Bone Microarchitecture Evaluation in an Osteoporosis Mouse Model
06:59

Trabecular Bone Microarchitecture Evaluation in an Osteoporosis Mouse Model

Published on: September 8, 2023

Microarchitectural changes in the aging skeleton.

Yankel Gabet1, Itai Bab

  • 1Department of Anatomy and Anthropology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel.

Current Osteoporosis Reports
|September 9, 2011
PubMed
Summary
This summary is machine-generated.

Aging bone weakens due to microstructural changes, not just mass loss. Advanced imaging reveals age-related thinning of trabecular bone and increased cortical porosity, impacting skeletal integrity.

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A Sectioning, Coring, and Image Processing Guide for High-Throughput Cortical Bone Sample Procurement and Analysis for Synchrotron Micro-CT
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A Sectioning, Coring, and Image Processing Guide for High-Throughput Cortical Bone Sample Procurement and Analysis for Synchrotron Micro-CT

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Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
07:56

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Published on: January 29, 2018

Related Experiment Videos

Last Updated: May 29, 2026

Trabecular Bone Microarchitecture Evaluation in an Osteoporosis Mouse Model
06:59

Trabecular Bone Microarchitecture Evaluation in an Osteoporosis Mouse Model

Published on: September 8, 2023

A Sectioning, Coring, and Image Processing Guide for High-Throughput Cortical Bone Sample Procurement and Analysis for Synchrotron Micro-CT
07:10

A Sectioning, Coring, and Image Processing Guide for High-Throughput Cortical Bone Sample Procurement and Analysis for Synchrotron Micro-CT

Published on: June 12, 2020

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
07:56

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Published on: January 29, 2018

Area of Science:

  • Bone biology and aging research
  • Skeletal microstructure analysis
  • Biomaterials and biomechanics

Background:

  • Age-related bone loss significantly impacts skeletal quality and increases fracture risk.
  • Microstructural changes in cortical and trabecular bone are critical determinants of bone strength.
  • Microcomputed tomography (μCT) has revolutionized the 3D analysis of bone microstructure.

Purpose of the Study:

  • To investigate age-related changes in bone microstructure using advanced imaging techniques.
  • To re-evaluate established findings on trabecular bone aging by addressing imaging biases.
  • To characterize microstructural alterations in cortical bone and their biomechanical consequences.

Main Methods:

  • Utilized microcomputed tomography (μCT) for high-resolution 3D imaging of bone microstructure.
  • Applied finite elemental analysis to predict biomechanical implications of observed microstructural changes.
  • Employed submicrometer resolution CT systems to analyze osteocyte lacunar density and microcracks.

Main Results:

  • Identified authentic age-related thinning of trabecular bone, masked by imaging biases in previous studies.
  • Demonstrated increased cortical porosity due to unbalanced osteonal remodeling and Haversian canal expansion.
  • Revealed age-related decrease in osteocyte lacunar density, micropetrosis, and increased microcracks in the mineralized matrix.

Conclusions:

  • Age-related skeletal weakening is driven by significant microstructural deterioration in both trabecular and cortical bone.
  • Advanced μCT imaging provides crucial insights into the mechanisms of bone aging and fragility.
  • Understanding these microstructural changes is vital for developing targeted interventions against age-related bone diseases.