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Related Concept Videos

Pain01:20

Pain

Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
Nociception01:44

Nociception

Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain. Thus, pain helps the...
Blood and Nerve Supply to the Bones01:29

Blood and Nerve Supply to the Bones

Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...

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Related Experiment Video

Updated: May 29, 2026

Monitoring Acupuncture Effects on Human Brain by fMRI
09:55

Monitoring Acupuncture Effects on Human Brain by fMRI

Published on: April 8, 2010

[Intrinsic brain activity with pain].

A Otti1, M Noll-Hussong

  • 1Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie, Klinikum rechts der Isar, Technische Universität München, München, Deutschland.

Schmerz (Berlin, Germany)
|September 9, 2011
PubMed
Summary
This summary is machine-generated.

The human brain exhibits organized spontaneous activity during rest, not random noise. This intrinsic neural activity, organized in resting state networks, plays a crucial role in processing both acute and chronic pain.

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Area of Science:

  • Neuroscience
  • Pain Research
  • Brain Imaging

Context:

  • Understanding human pain processing requires examining neural functions beyond nociception.
  • The brain exhibits spontaneous, low-frequency neural activity during resting states.

Purpose:

  • To discuss the role of intrinsic brain activity and resting state networks in pain processing.
  • To integrate findings from functional imaging studies on pain.

Summary:

  • The human brain's resting state activity is not random but organized into distinct networks.
  • These organized neural networks are implicated in the processing of acute and chronic pain.
  • Functional imaging studies provide insights into the involvement of these networks in pain.

Impact:

  • Highlights the importance of intrinsic brain activity in pain perception.
  • Suggests potential targets for understanding and managing pain conditions.
  • Emphasizes a shift from stimulus-response models to network-based approaches in pain research.