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Related Experiment Video

Updated: May 29, 2026

Surgical Treatment for Benign Prostatic Hyperplasia: Holmium Laser Enucleation of the Prostate (HoLEP).
06:04

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Published on: March 6, 2018

WITHDRAWN: Tamsulosin for benign prostatic hyperplasia.

Timothy J Wilt1, Roderick Macdonald, Indy Rutks

  • 1General Internal Medicine (111-0), VAMC, One Veterans Drive, Minneapolis, Minnesota, USA, 55417.

The Cochrane Database of Systematic Reviews
|September 9, 2011
PubMed
Summary

Tamsulosin offers mild to moderate symptom relief for benign prostatic hyperplasia (BPH) lower urinary tract symptoms (LUTS) compared to placebo. Higher doses increase adverse effects and withdrawals, with similar effectiveness to other alpha-blockers.

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Last Updated: May 29, 2026

Surgical Treatment for Benign Prostatic Hyperplasia: Holmium Laser Enucleation of the Prostate (HoLEP).
06:04

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Published on: March 6, 2018

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Photoselective Vaporesection of the Prostate via an End-firing Lithium Triborate Crystal Laser

Published on: May 9, 2018

Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing
05:25

Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing

Published on: August 14, 2019

Area of Science:

  • Urology
  • Pharmacology
  • Evidence-based Medicine

Background:

  • Benign prostatic hyperplasia (BPH) causes lower urinary tract symptoms (LUTS) in men.
  • Effective management of BPH-related LUTS is crucial for improving quality of life.

Purpose of the Study:

  • To systematically review the efficacy and safety of tamsulosin for treating LUTS associated with BPH.
  • To compare tamsulosin's effects against placebo, other BPH medications, and surgical interventions.

Main Methods:

  • Systematic review of randomized controlled trials involving men with BPH.
  • Searched major databases (MEDLINE, EMBASE, Cochrane Library) and contacted manufacturers.
  • Included studies with clinical outcomes, symptom scales, or urodynamic measurements (≥30 days duration).

Main Results:

  • Tamsulosin improved urinary symptoms and peak urine flow compared to placebo.
  • Effectiveness was comparable to other alpha-antagonists and phytotherapeutic agents.
  • Adverse effects, including dizziness and abnormal ejaculation, increased with higher tamsulosin doses (0.8 mg).

Conclusions:

  • Tamsulosin provides moderate symptom and flow improvement for BPH-related LUTS.
  • Higher doses offer minimal additional benefit but significantly increase adverse events and discontinuations.
  • Long-term efficacy and impact on BPH progression remain undetermined.