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Updated: May 29, 2026

Surgical Treatment for Benign Prostatic Hyperplasia: Holmium Laser Enucleation of the Prostate (HoLEP).
06:04

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WITHDRAWN: Terazosin for benign prostatic hyperplasia.

Timothy J Wilt1, R William Howe, Indy Rutks

  • 1General Internal Medicine (111-0), VAMC, One Veterans Drive, Minneapolis, Minnesota, USA, 55417.

The Cochrane Database of Systematic Reviews
|September 9, 2011
PubMed
Summary
This summary is machine-generated.

Terazosin effectively treats benign prostatic obstruction (BPO) urinary symptoms, improving flow rates more than placebo. However, it has more side effects than other alpha-blockers, leading to increased discontinuation.

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Area of Science:

  • Urology
  • Pharmacology

Background:

  • Benign prostatic obstruction (BPO) affects up to 70% of men over 60, causing lower urinary tract symptoms.
  • Alpha-blockers are a common treatment option for BPO symptoms.

Purpose of the Study:

  • To systematically review the effectiveness and adverse effects of terazosin for BPO-related urinary symptoms.

Main Methods:

  • Systematic review of randomized controlled trials (RCTs) of at least 1-month duration.
  • Included studies compared terazosin to placebo or active controls in men with symptomatic BPO.
  • Data on symptom scores, urodynamic measures, and adverse effects were extracted.

Main Results:

  • Terazosin improved symptom scores and flow rates compared to placebo and finasteride.
  • Effectiveness was similar to other alpha-blockers but less than transurethral microwave therapy (TUMT).
  • Adverse effects, including dizziness and postural hypotension, were more frequent than placebo, leading to higher discontinuation rates.

Conclusions:

  • Terazosin is effective in improving urinary symptoms and flow in BPO.
  • While effective, its adverse effect profile necessitates careful consideration due to increased discontinuation rates compared to other alpha-blockers.