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Related Experiment Video

Updated: May 29, 2026

Separation of Mouse Embryonic Facial Ectoderm and Mesenchyme

Separation of Mouse Embryonic Facial Ectoderm and Mesenchyme

Published on: April 12, 2013

Epigenetic integration of the developing brain and face.

Trish E Parsons¹, Eric J Schmidt, Julia C Boughner

¹McCaig Institute for Bone and Joint Health, University of Calgary, Calgary, Alberta, Canada.

Developmental Dynamics : an Official Publication of the American Association of Anatomists

|September 9, 2011

Summary

Brain and face development are linked, influencing craniofacial evolution. Forebrain size variations correlate with facial development, impacting prognathism and potentially causing orofacial clefts.

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Last Updated: May 29, 2026

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Published on: April 12, 2013

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Published on: July 12, 2012

Area of Science:

Evolutionary developmental biology
Comparative anatomy
Craniofacial development

Background:

The relationship between brain and face development is crucial for understanding craniofacial evolution.
Investigating brain-face integration provides insights into evolutionary constraints and developmental pathways.

Purpose of the Study:

To investigate the covariation between forebrain and midface development in mice.
To understand how brain-face integration influences craniofacial complex evolution.

Main Methods:

Studied covariation between forebrain and midface at gestational days 10-10.5.
Utilized four strains of laboratory mice for phenotypic variation analysis.

Main Results:

Phenotypic variation in the forebrain strongly correlates with facial development.
Forebrain size variation is linked to prognathism and facial prominence orientation.

Conclusions:

Brain-face integration is relevant to the causes of midfacial malformations like orofacial clefts.
This integration axis has significant implications for mammalian craniofacial evolutionary developmental biology.