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Multiplexed Isothermal Amplification Based Diagnostic Platform to Detect Zika, Chikungunya, and Dengue 1
Published on: March 13, 2018
Epidemiology of chikungunya in Malaysia: 2006-2009
1National Public Health Laboratory, Infectious Disease, Makmal Kesihatan Awam Kebangsaan, Kementerian Kesihatan, Lot 1853, Kg. Melayu, Sungai Buloh, Selangor 47000, Malaysia. chuakawbing@yahoo.com.sg
Insights
Chikungunya (CHIK) outbreaks occurred in Malaysia between 2006-2009, with laboratory confirmation in 45.9% of cases. Confirmed CHIK patients presented with higher rates of fever, arthralgia, and rash.
Area of Science:
- * Epidemiology
- * Infectious Diseases
- * Public Health
Background:
- * Chikungunya (CHIK) is a mosquito-borne viral illness causing significant public health concern.
- * Understanding CHIK epidemiology is crucial for effective outbreak response and control.
Purpose of the Study:
- * To analyze the epidemiological and clinical characteristics of chikungunya cases in Malaysia.
- * To identify patterns of chikungunya outbreaks from 2006 to 2009.
Main Methods:
- * Retrospective cross-sectional study utilizing laboratory and clinical data from referred patients.
- * Analysis of 13,759 patient records from January 2006 to December 2009.
- * Epidemic curves were plotted based on the onset of illness.
Main Results:
- * A total of 6314 (45.9%) laboratory-confirmed CHIK cases and 7445 (54.1%) epidemiologically linked cases were identified.
- * Three distinct CHIK outbreaks were observed: two in Perak (2006) and a larger, related outbreak originating in Johor (2008-2009) spreading across Malaysia.
- * Laboratory-confirmed CHIK patients were younger (mean age 37.0 years) and exhibited a higher incidence of fever, arthralgia, and rash compared to epidemiologically linked cases.
Conclusions:
- * Malaysia experienced significant chikungunya outbreaks between 2006 and 2009, with varying geographical and temporal patterns.
- * Clinical presentation, particularly fever, arthralgia, and rash, is indicative of CHIK, with higher prevalence in laboratory-confirmed cases.
- * The findings highlight the importance of laboratory confirmation for accurate CHIK diagnosis and surveillance.
Abstract:
This is a retrospective cross-sectional study based on the database of clusters of patients with clinical diagnosis of chikungunya (CHIK) that were referred to the National Public Health Laboratory for diagnostic investigations from January 2006 to December 2009. Of the 13,759 referred patients, a total of 6314 (45.9%) patients were laboratory confirmed to have CHIK and 7445 (54.1) patients were considered as clinical cases of CHIK by epidemiological link. Epidemic curves plotted using date of onset of illness for all referred clusters of cases showed that there were three unrelated outbreaks of CHIK in Malaysia from 2006 to 2009. There were two small outbreaks that occurred within the state of Perak in 2006. The cluster of cases in 2008 and 2009 were of related outbreak which started in Johor state and subsequently spread to various parts of Malaysia. The mean age of the patients was 37.0 years old and those patients in the laboratory confirmed group were significantly younger than those in the epidemiological linked group. The main presenting clinical features recorded in this study were fever, arthralgia, myalgia and rashes. Those patients in the laboratory confirmed group had a significant higher incidence of fever, arthralgia and rash than those in the epidemiological linked group.
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