Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Bioreactor Controls-II

Bioreactor Controls-II

In aerobic fermentations, oxygen is vital for microbial growth and metabolite production. Since air comprises only about 20% oxygen and the gas is poorly soluble in water—just 9 ppm at 20°C—supplying sufficient oxygen becomes a critical challenge, especially in high-demand processes like yeast growth or citric acid production. Even a fully saturated broth may offer only a few seconds of oxygen availability.To address this, sterile or scrubbed air is introduced into the fermentor via a sparger...

Bioreactor Controls-I

Bioreactor Controls-I

Maintaining optimal conditions within fermenters is essential for maximizing microbial productivity and ensuring process efficiency. This lesson focuses on key parameters—temperature, foam, pH, carbon dioxide, oxygen, and pressure—and their precise measurement and control strategies in fermentation systems.Temperature ControlTemperature regulation is critical due to the exothermic nature of many fermentation processes. In small laboratory fermenters, temperature is commonly monitored using...

Bioreactor Design and Operational System

Bioreactor Design and Operational System

Bioreactors are engineered vessels designed to cultivate microorganisms under controlled conditions for industrial bioprocessing. They maintain sterility and allow precise regulation of pH, temperature, oxygen, and nutrient levels to optimize microbial growth and metabolite production. Bioreactors range from small laboratory units of 1 liter to industrial systems holding up to 500,000 liters, though only about 75% of their volume is actively used for fermentation. The remaining headspace...

Bioreactor Controls-III

Bioreactor Controls-III

Strain improvement is a foundational strategy in industrial microbiology aimed at maximizing microbial productivity, particularly because natural isolates typically yield commercially valuable products in very low concentrations. Although optimizing the culture medium and environmental conditions can improve yields, these adjustments are inherently limited by the organism’s genetic potential. As a result, the focus shifts toward genetic modifications to enhance biosynthetic capacity. The...

Upstream Processing

Upstream Processing

Upstream processing represents a critical phase in biomanufacturing, wherein biological systems such as microorganisms, mammalian cells, or insect cells are cultivated to produce therapeutic proteins, vaccines, enzymes, or other biologically derived products. This phase encompasses all steps from the selection and genetic manipulation of the production organism to the cultivation of cells in bioreactors under tightly controlled environmental conditions.Host Selection and Genetic OptimizationThe...

Control Systems

Control Systems

Control systems are everywhere in contemporary society, influencing diverse applications from aerospace to automated manufacturing. These systems can be found naturally within biological processes, such as blood sugar regulation and heart rate adjustment in response to stress, as well as in man-made systems like elevators and automated vehicles. A control system is essentially a network of subsystems and processes that collaboratively convert specific inputs into desired outputs.
At the heart...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Strategic framework for sustainable centralisation of wastewater treatment plants: integrating economic and environmental analysis.

Bioresource technology·2026

Same author

Specificity Evaluation of a Polyprotein-Based ELISA Designed for the Detection of Paratuberculosis in Multiple Species.

Veterinary medicine international·2026

Same author

PET/CT in breast cancer.

Revista espanola de medicina nuclear e imagen molecular·2025

Same author

State of the art and future perspectives of new radinuclides in Nuclear Medicine: Part III.

Revista espanola de medicina nuclear e imagen molecular..·2025

Same author

State of the art and future perspectives of new radionuclides in Nuclear Medicine. Part II.

Revista espanola de medicina nuclear e imagen molecular·2025

Same author

State of the art and future perspectives of new radionuclides in Nuclear Medicine.

Revista espanola de medicina nuclear e imagen molecular·2025

Search research articles

Related Experiment Video

Updated: May 29, 2026

Coupling Carbon Capture from a Power Plant with Semi-automated Open Raceway Ponds for Microalgae Cultivation

Coupling Carbon Capture from a Power Plant with Semi-automated Open Raceway Ponds for Microalgae Cultivation

Published on: August 14, 2020

A knowledge-based control system for air-scour optimisation in membrane bioreactors.

G Ferrero¹, H Monclús, L Sancho

¹Laboratory of Chemical and Environmental Engineering (LEQUiA), Environmental Institute, University of Girona, Girona E17071, Spain.

Water Science and Technology : a Journal of the International Association on Water Pollution Research

|September 10, 2011

Summary

This summary is machine-generated.

Membrane bioreactors (MBRs) are mature wastewater treatment technologies. A new knowledge-based decision support system (DSS) optimizes MBR operation, automating air-scour and minimizing energy use for cost savings.

More Related Videos

Generic Protocol for Optimization of Heterologous Protein Production Using Automated Microbioreactor Technology

Generic Protocol for Optimization of Heterologous Protein Production Using Automated Microbioreactor Technology

Published on: December 15, 2017

A Novel Bioreactor for High Density Cultivation of Diverse Microbial Communities

A Novel Bioreactor for High Density Cultivation of Diverse Microbial Communities

Published on: December 25, 2015

Related Experiment Videos

Last Updated: May 29, 2026

Coupling Carbon Capture from a Power Plant with Semi-automated Open Raceway Ponds for Microalgae Cultivation

Coupling Carbon Capture from a Power Plant with Semi-automated Open Raceway Ponds for Microalgae Cultivation

Published on: August 14, 2020

Generic Protocol for Optimization of Heterologous Protein Production Using Automated Microbioreactor Technology

Generic Protocol for Optimization of Heterologous Protein Production Using Automated Microbioreactor Technology

Published on: December 15, 2017

A Novel Bioreactor for High Density Cultivation of Diverse Microbial Communities

A Novel Bioreactor for High Density Cultivation of Diverse Microbial Communities

Published on: December 25, 2015

Area of Science:

Environmental Engineering
Water Treatment Technologies

Background:

Membrane bioreactors (MBRs) offer compact wastewater treatment with high effluent quality, suitable for stringent discharge limits and water reuse.
Despite technical maturity, MBRs exhibit higher operational costs than conventional methods, necessitating energy saving and optimization strategies.

Purpose of the Study:

To develop a knowledge-based decision support system (DSS) for integrated operation and remote control of MBR processes.
To automate air-scour consumption and minimize energy usage in MBR systems.

Main Methods:

Development of a knowledge-based control module integrated into a DSS.
Implementation of automated control for biological and physical (filtration, backwashing, relaxation) MBR processes.

Main Results:

The DSS enables integrated operation and remote control of MBRs.
The knowledge-based control module effectively automates air-scour consumption.
Significant potential for energy consumption minimization was identified.

Conclusions:

The developed DSS provides a viable solution for optimizing MBR operation.
Automated control through the DSS can lead to reduced operational costs and enhanced energy efficiency in MBRs.
This approach supports the wider adoption of MBR technology by addressing cost concerns.