Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Types of Step-Growth Polymers: Polyesters

Types of Step-Growth Polymers: Polyesters

The introduction of polyesters has brought major development to the textile industry. The wrinkle-free behavior of polyester blends has eliminated the need for starching and ironing clothes.
Polyesters are commonly prepared from terephthalic acid and ethylene glycol; the crude product is known as poly(ethylene terephthalate) or PET. However, polyesters are synthesized industrially by transesterification of dimethyl terephthalate with ethylene glycol at 150 °C. The two reactants and the polymer...

Modified-Release Drug Delivery Systems: Rate-Programmed II

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The influence of scaffold fibre architecture on tenocyte tissue production under intermittent dynamic culture.

Acta biomaterialia·2026

Same author

Thermally stable, photocrossinkable and biocompatible copolymers for melt electrowriting.

Biofabrication·2025

Same author

Probing the effects of polysaccharide hydrogel composition on the viability and pro-angiogenic function of human adipose-derived stromal cells.

Journal of biomedical materials research. Part A·2024

Same author

Tendon Decellularized Matrix Modified Fibrous Scaffolds with Porous and Crimped Microstructure for Tendon Regeneration.

ACS applied bio materials·2024

Same author

Visible light degradable micelles for intraocular corticosteroid delivery.

Journal of materials chemistry. B·2024

Same author

<i>In situ</i> forming, mechanically resilient hydrogels prepared from 4a-[PEG-<i>b</i>-PTMC-Ac] and thiolated chondroitin sulfate for nucleus pulposus cell delivery.

Journal of materials chemistry. B·2024

Same journal

Metal-Ion-Modulated Stabilization of Intermediates in Diphenylalanine and Phenylalanine Self-Assembly: Roles of Metal-Ion-Specific Salt Bridges and Hydrophobic Interactions.

Biomacromolecules·2026

Same journal

Understanding Processing-Structure-Property Relationships in Spun Spidroin-Mimetic Fibers Using Molecular Dynamics Simulation.

Biomacromolecules·2026

Same journal

Exploring the Antibacterial Potential of Bis-MPA Dendrimers Bearing Cu(II) and Zn(II) Complexes.

Biomacromolecules·2026

Same journal

Toward Sustainable Optics: Fully Biomass-Based Vitrimer Film for Near-Infrared Transparency.

Biomacromolecules·2026

Same journal

Poly(furfuryl alcohol) as a Surface Modifier for Cellulose Nanocrystals Reinforced HDPE Nanocomposites.

Biomacromolecules·2026

Same journal

Cutinase Adsorption to Polyester Surfaces Modulates Dissolved Oligomer Speciation during Enzymatic Depolymerization.

Biomacromolecules·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 29, 2026

Melt Electrospinning Writing of Three-dimensional Poly(ε-caprolactone) Scaffolds with Controllable Morphologies for Tissue Engineering Applications

Melt Electrospinning Writing of Three-dimensional Poly(ε-caprolactone) Scaffolds with Controllable Morphologies for Tissue Engineering Applications

Published on: December 23, 2017

Surface eroding, liquid injectable polymers based on 5-ethylene ketal ε-caprolactone.

Oladunni Iyabo Babasola¹, Brian G Amsden

¹Department of Chemical Engineering, Queen's University, Kingston, Ontario K7L 3N6, Canada.

Biomacromolecules

|September 10, 2011

Summary

This summary is machine-generated.

Injectable hydrophobic polymers made from 5-ethylene ketal ε-caprolactone (EKC) and D,L-lactide offer tunable viscosity for drug delivery. These polymers exhibit controlled degradation and low cytotoxicity, indicating potential for localized drug depots.

More Related Videos

Composite Scaffolds of Interfacial Polyelectrolyte Fibers for Temporally Controlled Release of Biomolecules

Composite Scaffolds of Interfacial Polyelectrolyte Fibers for Temporally Controlled Release of Biomolecules

Published on: August 19, 2015

Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications

Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications

Published on: August 28, 2015

Related Experiment Videos

Last Updated: May 29, 2026

Melt Electrospinning Writing of Three-dimensional Poly(ε-caprolactone) Scaffolds with Controllable Morphologies for Tissue Engineering Applications

Melt Electrospinning Writing of Three-dimensional Poly(ε-caprolactone) Scaffolds with Controllable Morphologies for Tissue Engineering Applications

Published on: December 23, 2017

Composite Scaffolds of Interfacial Polyelectrolyte Fibers for Temporally Controlled Release of Biomolecules

Composite Scaffolds of Interfacial Polyelectrolyte Fibers for Temporally Controlled Release of Biomolecules

Published on: August 19, 2015

Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications

Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications

Published on: August 28, 2015

Area of Science:

Biomaterials Science
Polymer Chemistry
Drug Delivery Systems

Background:

Injectable hydrophobic polymers are crucial for localized drug delivery depot systems.
Controlling polymer properties like viscosity and degradation rate is essential for effective drug release.

Purpose of the Study:

To synthesize and characterize low molecular weight polymers of 5-ethylene ketal ε-caprolactone (EKC) and its copolymers with D,L-lactide.
To evaluate their suitability as injectable depot systems for localized drug delivery.

Main Methods:

Synthesis of EKC homopolymers and EKC-D,L-lactide copolymers using different initiators (methoxy poly(ethylene glycol) and octan-1-ol).
Assessment of polymer properties including viscosity, amorphous nature, and degradation rates in vitro.
Cytotoxicity evaluation of the hydrolyzed EKC monomer using 3T3 fibroblast cells.

Main Results:

Polymer viscosity was adjustable via initiator choice and copolymerization with D,L-lactide.
Copolymers with D,L-lactide (DLLA) degraded faster than EKC homopolymers, which showed a constant degradation rate.
Hydrolyzed EKC monomer exhibited cytotoxicity comparable to ε-caprolactone.

Conclusions:

EKC-based polymers and their copolymers with D,L-lactide are promising candidates for injectable drug delivery systems.
Tunable viscosity and controlled degradation rates enhance their potential for localized drug depots.
Low cytotoxicity suggests good biocompatibility for in vivo applications.