Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Mesenchymal Stem Cells

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...

Stem Cell Culture

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...

Adult Stem Cells

Adult Stem Cells

Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously renew...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Secondary Oral Vancomycin Prophylaxis and <i>Clostridioides difficile</i> Infection in Children and Young Adults With Cancer: A Retrospective Cohort Study.

Open forum infectious diseases·2026

Same author

Utility of Computed Tomography Surveillance of Asymptomatic Infection in Children and Young Adults Before Allogeneic Hematopoietic Stem Cell Transplant.

Pediatric blood & cancer·2026

Same author

Negative Selection Maintains Grossly Altered but Broadly Stable Karyotypes in Metastatic Colorectal Cancer.

Cancer discovery·2026

Same author

Correction: Inhibition of astrocyte signaling leads to sex-specific changes in microglia phenotypes in a diet-based model of cerebral small vessel disease.

Journal of neuroinflammation·2025

Same author

Central cytometabolic functional vascular coupling in health and disease.

npj metabolic health and disease·2025

Same author

Epidemiology of Invasive Fungal Disease in Pediatric Heart Transplant Recipients.

Journal of the Pediatric Infectious Diseases Society·2025

Search research articles

Related Experiment Video

Updated: May 29, 2026

An Enzymatic Method to Rescue Mesenchymal Stem Cells from Clotted Bone Marrow Samples

An Enzymatic Method to Rescue Mesenchymal Stem Cells from Clotted Bone Marrow Samples

Published on: April 12, 2015

Mesenchymal stem cells: from experiment to clinic.

William R Otto¹, Nicholas A Wright

¹Histopathology Laboratory, Cancer Research UK, London Research Institute, 44, Lincoln's Inn Fields, London WC2A 3LY, UK. w.r.otto@qmul.ac.uk.

Fibrogenesis & Tissue Repair

|September 10, 2011

Summary

Adult mesenchymal stem cells (MSCs) show potential in tissue repair but have dual roles in healing and tumor formation. Clinical applications require careful understanding of their complex properties for patient safety.

More Related Videos

Isolation of Perivascular Multipotent Precursor Cell Populations from Human Cardiac Tissue

Isolation of Perivascular Multipotent Precursor Cell Populations from Human Cardiac Tissue

Published on: October 8, 2016

Related Experiment Videos

Last Updated: May 29, 2026

An Enzymatic Method to Rescue Mesenchymal Stem Cells from Clotted Bone Marrow Samples

An Enzymatic Method to Rescue Mesenchymal Stem Cells from Clotted Bone Marrow Samples

Published on: April 12, 2015

Isolation of Perivascular Multipotent Precursor Cell Populations from Human Cardiac Tissue

Isolation of Perivascular Multipotent Precursor Cell Populations from Human Cardiac Tissue

Published on: October 8, 2016

Area of Science:

Regenerative Medicine
Cell Biology
Immunology

Background:

Adult mesenchymal stem cells (MSCs) are multipotent stem cells with broad differentiation potential.
MSCs can be isolated from various tissues beyond bone marrow, including adipose tissue and umbilical cord.
Their immunomodulatory properties and potential roles in tissue repair are areas of intense research.

Purpose of the Study:

To review the capacity of MSCs to influence repair processes in organs such as the liver, kidney, heart, and intestines.
To discuss the dual nature of MSCs, highlighting their low immunogenicity for transplantation versus their role in xenograft tumor formation.
To evaluate recent clinical findings on MSC safety and therapeutic potential.

Main Methods:

Literature review of preclinical and clinical studies on MSCs.
Analysis of MSC differentiation and immunomodulatory functions.
Examination of MSCs' role in organ repair and xenograft models.

Main Results:

MSCs contribute to wound healing and may aid in epithelial regeneration.
MSCs demonstrate potential in modulating repair in liver, kidney, heart, and intestinal tissues.
While MSCs are less immunogenic, their involvement in human tumor xenografts raises safety concerns.
Clinical studies indicate MSCs are safe in various pathologies, but long-term effects require further investigation.

Conclusions:

MSCs possess significant therapeutic potential for tissue repair and regeneration.
Understanding and controlling the opposing properties of MSCs is crucial for safe clinical translation.
Further research is needed to fully harness MSCs' benefits while mitigating potential risks.