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Published on: June 22, 2017
Reorganization of striatal inhibitory microcircuits leads to pathological synchrony in the Basal Ganglia
Pauline Belujon1, Anthony A Grace
1Departments of Neuroscience, Psychiatry, and Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA. belujon@pitt.edu
Abstract:
Neural synchronization plays an important role in information flow in the nervous system under healthy and pathological conditions. In this issue of Neuron, Gittis et al. show that reorganization of striatal microcircuits promotes synchronous activity and may underlie the pathological network oscillations at the root of motor symptoms described in Parkinson's disease.
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