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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the addition of a...
Translational Regulation01:29

Translational Regulation

Translational regulation in prokaryotes ensures efficient protein synthesis by controlling ribosome access to mRNA. This regulation is mediated by secondary RNA structures, including translational riboswitches, RNA thermometers, and small RNAs (sRNAs), which respond to intracellular and environmental signals to modulate gene expression.Translational RiboswitchesRiboswitches in the leader region of mRNAs can regulate translation by altering the accessibility of the Shine-Dalgarno (SD) sequence,...

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Related Experiment Video

Updated: May 29, 2026

Detection of RNA-binding Proteins by In Vitro RNA Pull-down in Adipocyte Culture
10:34

Detection of RNA-binding Proteins by In Vitro RNA Pull-down in Adipocyte Culture

Published on: July 22, 2016

A possible role for long non-coding RNA in modulating signaling pathways.

Barak Rotblat1, Gabriel Leprivier, Poul H B Sorensen

  • 1Department of Molecular Oncology, BC Cancer Research Center, University of British Columbia, Vancouver, BC, Canada.

Medical Hypotheses
|September 10, 2011
PubMed
Summary
This summary is machine-generated.

Long non-coding RNAs (lncRNAs) may act as crucial signaling modulators, linking proteins like Ras to specific downstream pathways. Understanding lncRNA profiles could predict cancer-driving pathways activated by mutant Ras proteins.

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Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR
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Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR

Published on: March 1, 2019

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Last Updated: May 29, 2026

Detection of RNA-binding Proteins by In Vitro RNA Pull-down in Adipocyte Culture
10:34

Detection of RNA-binding Proteins by In Vitro RNA Pull-down in Adipocyte Culture

Published on: July 22, 2016

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR
13:04

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR

Published on: March 1, 2019

Area of Science:

  • Molecular Biology
  • Cancer Biology
  • RNA Biology

Background:

  • Signaling proteins, like Ras GTPase, interact with multiple targets context-dependently.
  • Hyperactive Ras, common in cancers, activates diverse downstream pathways, but target selection remains unclear.
  • Long non-coding RNAs (lncRNAs) are increasingly recognized for biological functions, yet most remain uncharacterized.

Purpose of the Study:

  • To investigate the hypothesis that lncRNAs function as signaling modulators, linking proteins to specific downstream targets.
  • To explore the role of lncRNAs in mediating Ras signaling in specific cellular and disease contexts.
  • To determine if lncRNA profiles can predict pathways activated by mutant Ras in cancer.

Main Methods:

  • Literature review and synthesis of existing studies on protein-protein interactions, Ras signaling, and lncRNA functions.
  • Analysis of evidence supporting lncRNA roles in protein complex regulation and cancer-specific expression.
  • Conceptual framework development for lncRNA-mediated signal transduction.

Main Results:

  • lncRNAs possess the structural and functional capacity to bind and regulate protein complexes.
  • Specific lncRNAs are differentially expressed in cancers, potentially influencing tumor progression.
  • lncRNAs can discriminate between multiple potential effectors, suggesting a role in precise biological regulation.

Conclusions:

  • lncRNAs are hypothesized to be key players in signal propagation, acting as context-specific adaptors for signaling proteins.
  • Identifying lncRNA profiles may enable prediction of mutant Ras-activated pathways in specific cancers.
  • This research expands the understanding of signal transduction network wiring within biological contexts.