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A compound isolated from Schisandra chinensis induces apoptosis
Doseok Hwang1, Soon Young Shin, Younggiu Lee
1Division of Bioscience and Biotechnology, BMIC, Konkuk University, Seoul 143-701, Republic of Korea.
Bioorganic & Medicinal Chemistry Letters
|September 10, 2011
Summary
Schisandra chinensis compound Gomisin A induces apoptosis in colon cancer cells. This study identified Gomisin A
Area of Science:
- Phytochemistry
- Cancer Biology
- Pharmacology
Background:
- Schisandra chinensis is recognized for its five tastes and diverse physiological effects.
- Previous research highlights its impact on cardiovascular, gastrointestinal, and central nervous systems, as well as anti-inflammatory and stress-protective properties.
- The anti-cancer potential of Schisandra chinensis, particularly against colon carcinoma HCT-116 cells, remained unexplored.
Purpose of the Study:
- To isolate and identify a compound from Schisandra chinensis with apoptosis-inducing activity against colon carcinoma HCT-116 cells.
- To investigate the mechanism of action of the identified compound in HCT-116 cells.
Main Methods:
- Isolation and identification of an active compound from Schisandra chinensis.
- Assessment of the compound's apoptotic activity in colon carcinoma HCT-116 cells.
- Analysis of caspase-7 cleavage as a mechanism of apoptosis induction.
- Evaluation of long-term cell survival using clonogenic assays.
Main Results:
- An active compound, identified as Gomisin A, was successfully isolated from Schisandra chinensis.
- Gomisin A demonstrated significant apoptotic activity in colon carcinoma HCT-116 cells.
- Apoptosis was mediated through caspase-7 cleavage.
- Long-term survival assays confirmed the anti-proliferative effects of Gomisin A on HCT-116 cells.
Conclusions:
- Gomisin A, isolated from Schisandra chinensis, exhibits potent anti-cancer properties against colon carcinoma HCT-116 cells.
- The compound induces apoptosis via caspase-7 activation, representing a novel therapeutic avenue.
- Further research into Gomisin A as a potential chemotherapeutic agent for colon cancer is warranted.
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