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Related Concept Videos

Anatomical Terminology01:20

Anatomical Terminology

Knowledge of anatomy is essential to understand human biology and medicine. Anatomists and health care professionals use standard terminology to describe the human body with more precision and no ambiguity. Anatomical terms have mostly Greek and Latin-derived roots. Because these languages are rarely used in conversation, the meaning of words remains the same. Each term is made up of a root in between the prefixes and suffixes. The root of a term often refers to an organ, tissue, or condition,...
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In addition to multiple alleles at the same locus influencing traits, numerous genes or alleles at different locations may interact and influence phenotypes in a phenomenon called epistasis. For example, rabbit fur can be black or brown depending on whether the animal is homozygous dominant or heterozygous at a TYRP1 locus. However, if the rabbit is also homozygous recessive at a locus on the tyrosinase gene (TYR), it will have an unshaded coat that appears white, regardless of its TYRP1...
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Although Mendel chose seven unrelated traits in peas to study gene segregation, most traits involve multiple gene interactions that create a spectrum of phenotypes. When the interaction of various genes or alleles at different locations influences a phenotype, this is called epistasis. Epistasis often involves one gene masking or interfering with the expression of another (antagonistic epistasis). Epistasis often occurs when different genes are part of the same biochemical pathway. The...
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Epigenetic Regulation01:46

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

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Use of the EpiAirway Model for Characterizing Long-term Host-pathogen Interactions
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Published on: September 2, 2011

EPI - In the beginning.

Sir Peter Mansfield1

  • 1Schools of Physics and Astronomy, The University of Nottingham, University Park, Nottingham NG7 2RD, UK.

Journal of Magnetic Resonance (San Diego, Calif. : 1997)
|September 10, 2011
PubMed
Summary
This summary is machine-generated.

This study recalls the foundational ideas and thoughts behind the creation of the Evidence-based Practice Improvement (EPI) initiative. It explores the conceptualization process that led to the development of EPI.

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Area of Science:

  • Health Services Research
  • Evidence-Based Practice

Background:

  • The Evidence-based Practice Improvement (EPI) initiative was established to enhance healthcare quality.
  • Understanding the origins of EPI is crucial for its continued development and application.

Purpose of the Study:

  • To document and reflect on the intellectual journey and conceptualization process that led to the creation of EPI.
  • To provide historical context for the foundational ideas driving the EPI initiative.

Main Methods:

  • Qualitative review of historical documents and records pertaining to EPI's inception.
  • Recollection and synthesis of the key ideas and thought processes from the individuals involved in EPI's creation.

Main Results:

  • The creation of EPI was driven by a convergence of specific needs and innovative thinking in healthcare improvement.
  • Key conceptual frameworks and guiding principles were identified as central to EPI's initial design.

Conclusions:

  • The foundational ideas behind EPI remain relevant for current and future healthcare improvement efforts.
  • Documenting the genesis of such initiatives offers valuable insights for the field of evidence-based practice.