Recurrence of central odontogenic fibroma: a rare case
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Updated: May 29, 2026

Lateral Molar Approach-Driven Transoral Endoscopic Procedure for Benign Infratemporal Fossa Tumor Resection
Published on: August 15, 2025
Auremir Rocha Melo1, Thiago de Santana Santos, Marcelo Fernando do Amaral
1Department of Oral and Maxillofacial Surgery, University of Pernambuco (FOP/UPE), Camaragibe, PE, Brazil.
Abstract:
Central odontogenic fibroma (COF) is a rare, benign, painless, slow-growing tumor associated with expansion of the bone cortex. Histologically, it consists of fibrous connective tissue that contains multiple islands of odontogenic epithelium. Some lesions have diffuse spherical calcifications that usually are related to islands or cords of epithelium. The majority of cases respond well to conservative treatment such as enucleation and the prognosis is favorable; recurrences are rare. This article presents a rare case of COF that was located in the anterior region of the maxilla and treated with enucleation; the case recurred five years following the initial treatment.