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Updated: May 29, 2026

Minimal Erythema Dose (MED) Testing

Minimal Erythema Dose (MED) Testing

Published on: May 28, 2013

Oral erythema multiforme major: a triple case report.

Ronald S Brown¹, Andre A Farquharson, Iris Morton

¹Department of Oral Diagnostic Services, Howard University College of Dentistry, Washington, DC, USA.

General Dentistry

|September 10, 2011

Summary

Erythema multiforme (EM) major, often triggered by herpes infections, presents with severe oral sores. Topical and systemic steroids effectively treated these cases, highlighting the importance of dental awareness for diagnosis and management.

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Published on: September 20, 2018

Area of Science:

Dermatology
Oral Medicine
Infectious Diseases

Background:

Erythema multiforme (EM) is an acute mucocutaneous condition often triggered by infections, particularly herpes simplex virus.
Distinguishing EM major from Stevens-Johnson syndrome is crucial due to differing management and prognosis.
Oral mucosal lesions are a common and significant manifestation of EM major.

Observation:

Three cases of EM major with prominent oral lesions are presented: two males (28 and 10 years old) and one female (19 years old).
All patients reported a history suggestive of preceding oral herpetic infection.
Clinical presentation included oral vesiculoerosive lesions consistent with EM major.

Findings:

Successful resolution of oral lesions was achieved in all three patients using a combination of topical and systemic corticosteroids.
The cases underscore the link between herpetic infections and the development of EM major.
Effective management strategies are available for EM major with oral manifestations.

Implications:

Dentists must be aware of the clinical presentation and etiology of EM major to ensure accurate diagnosis.
Understanding the differences between EM and Stevens-Johnson syndrome is vital for appropriate patient care.
Prompt and correct management, including corticosteroid therapy, can lead to favorable outcomes in EM major.