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Non-Canonical Wnt Signaling Pathways

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...

Non-Canonical Wnt Signaling Pathways

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...

Canonical Wnt Signaling Pathway

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...

Canonical Wnt Signaling Pathway

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...

Catenins

Catenins

Catenins are characterized by multiple binding domains and dynamic structures that allow them to function as linker proteins in cell junction complexes. All catenins, except α-catenin, contain a characteristic protein sequence called the armadillo repeat and are therefore also called armadillo proteins.
Catenins in Cell Junctions
Catenins bind to cell adhesion molecules such as cadherins and link them to different cytoskeletal proteins depending on the type of cell junction. At the adherens...

Notch Signaling Pathway

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...

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Related Experiment Video

Updated: May 29, 2026

Modeling Paracrine Noncanonical Wnt Signaling In Vitro

Modeling Paracrine Noncanonical Wnt Signaling In Vitro

Published on: December 10, 2021

Wnt/Ca2+ signaling pathway: a brief overview.

¹Crystallography and Molecular Biology Division, Saha Institute of Nuclear Physics, Kolkata, India. dantara1@hotmail.com

Acta Biochimica Et Biophysica Sinica

|September 10, 2011

Summary

The Wnt/Ca(2+) signaling pathway, a less-understood non-canonical Wnt cascade, plays roles beyond development. This review explores its fundamental and emerging concepts.

Area of Science:

Cell Biology
Molecular Biology
Biochemistry

Background:

Non-canonical Wnt signaling pathways, including Wnt/Ca(2+), are less characterized than the canonical Wnt/β-catenin pathway.
These pathways are diverse and exhibit significant overlap, complicating their study.
The Wnt/Ca(2+) pathway, initially recognized for its role in development, is now implicated in various molecular phenomena.

Purpose of the Study:

To provide a concise overview of the Wnt/Ca(2+) signaling pathway.
To highlight fundamental and evolving concepts of this signaling cascade.
To address the enigmatic aspects of Wnt/Ca(2+) pathway function.

Main Methods:

Literature review of existing research on Wnt/Ca(2+) signaling.
Synthesis of information on diverse non-canonical Wnt pathways.

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The Soft Agar Colony Formation Assay

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Published on: October 27, 2014

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Last Updated: May 29, 2026

Modeling Paracrine Noncanonical Wnt Signaling In Vitro

Modeling Paracrine Noncanonical Wnt Signaling In Vitro

Published on: December 10, 2021

The Soft Agar Colony Formation Assay

The Soft Agar Colony Formation Assay

Published on: October 27, 2014

Analysis of the Wnt/Ca(2+) pathway's role in development and other molecular processes.

Main Results:

The Wnt/Ca(2+) pathway is a complex signaling cascade with diverse non-canonical counterparts.
Evidence suggests its involvement in numerous molecular phenomena beyond its established developmental roles.
Many facets of the Wnt/Ca(2+) pathway remain to be fully elucidated.

Conclusions:

The Wnt/Ca(2+) pathway is a critical signaling cascade with expanding implications.
Further research is needed to unravel the complexities and full scope of its functions.
Understanding this pathway is essential for comprehending various biological processes.