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A Contusive Model of Unilateral Cervical Spinal Cord Injury Using the Infinite Horizon Impactor
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Published on: July 24, 2012

Sildenafil-induced cervical spinal cord infarction.

J E Walden1, M Castillo

  • 1Department of Radiology, Division of Neuroradiology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA. janicawalden@hotmail.com

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Summary

Sildenafil (Viagra) combined with hypertension drugs may cause acute cervical spinal cord infarction. Magnetic resonance imaging with diffusion-weighted imaging (DWI) is vital for diagnosis.

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Area of Science:

  • Neurology
  • Cardiology
  • Pharmacology

Background:

  • Spinal cord infarction is a rare but serious neurological emergency.
  • Sildenafil is a phosphodiesterase-5 inhibitor used for erectile dysfunction.
  • Hypertension is a common comorbidity associated with erectile dysfunction.

Observation:

  • A patient developed acute, rapidly progressive neurological deficits.
  • The patient was concurrently using sildenafil and hypertension medication.

Findings:

  • Cervical spinal cord infarction was diagnosed.
  • The infarction was potentially linked to the combination of sildenafil and antihypertensive therapy.
  • Diffusion-weighted imaging (DWI) on MRI was essential for diagnosis.

Implications:

  • This case highlights a potential drug interaction between sildenafil and hypertension medications leading to spinal cord ischemia.
  • Clinicians should consider spinal cord infarction in patients presenting with acute neurological deficits, especially those on sildenafil and antihypertensive agents.
  • Further research is warranted to elucidate the mechanism and incidence of this adverse event.