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Related Concept Videos

Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
Renal Corpuscle01:20

Renal Corpuscle

The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous capillaries...
Diabetic Nephropathy01:28

Diabetic Nephropathy

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Nephrons01:10

Nephrons

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Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...
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Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...

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Updated: May 29, 2026

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway
07:15

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Membranous nephropathy with crescents.

Amanda Walton Basford1, Julia Lewis, Jamie P Dwyer

  • 1Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Journal of the American Society of Nephrology : JASN
|September 10, 2011
PubMed
Summary

Membranous nephropathy can present with crescents, indicating a secondary cause beyond primary disease. This case highlights distinct coexisting glomerulonephritis, impacting diagnosis and treatment.

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Area of Science:

  • Nephrology
  • Pathology

Background:

  • Membranous nephropathy is a frequent cause of nephrotic syndrome in adults.
  • It can be primary or secondary to conditions like lupus, infections, or certain drugs.

Observation:

  • Rapidly declining renal function in membranous nephropathy can signal complications like thrombosis or superimposed renal parenchymal disease.
  • The presence of crescents in membranous nephropathy is uncommon and suggests an underlying condition.

Findings:

  • Crescents in membranous nephropathy may indicate lupus nephritis or separate glomerulonephritis, such as anti-GBM disease or ANCA-associated vasculitis.
  • This case presents renal biopsy findings of coexisting membranous nephropathy and crescentic glomerulonephritis.

Implications:

  • Understanding the coexistence of these lesions is crucial for accurate diagnosis and management of kidney disease.
  • This review discusses potential pathogenetic mechanisms for combined membranous and crescentic glomerulonephritis.