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Related Experiment Video

Updated: May 29, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

Th subset balance in lupus nephritis.

Katsuhisa Miyake¹, Mitsuteru Akahoshi, Hitoshi Nakashima

¹Division of Nephrology and Rheumatology, Department of Internal Medicine, Faculty of Medicine, Fukuoka University, Fukuoka 814-0180, Japan. kmiyake@fukuoka-u.ac.jp

Journal of Biomedicine & Biotechnology

|September 10, 2011

Summary

Lupus nephritis (LN) arises from complex immune responses. Different T-helper cell subsets, specifically Th1 and Th2 cytokines, dictate the distinct histological patterns observed in lupus nephritis.

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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

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The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

Published on: November 1, 2015

Area of Science:

Immunology
Nephrology
Pathology

Background:

Lupus nephritis (LN) is a significant complication of systemic lupus erythematosus (SLE).
The precise pathogenetic mechanisms underlying different histological patterns of LN remain unclear.
SLE is characterized by immune dysregulation involving various lymphocyte subsets and cytokine profiles.

Purpose of the Study:

To elucidate the distinct roles of T-helper cell subsets and their associated cytokines in the pathogenesis of different lupus nephritis histopathological types.
To investigate the hypothesis that the balance of Th1/Th2 cytokines is a critical determinant of LN histopathology.

Main Methods:

Analysis of cytokine profiles (Th1, Th2, IL-17) in patients with lupus nephritis.
Correlation of specific cytokine patterns with distinct histological classifications of LN, including diffuse proliferative lupus nephritis (DPLN) and membranous lupus nephritis (MLN).

Main Results:

Evidence suggests a crucial role for Th1 and IL-17-producing T (Th17) cells in the development of diffuse proliferative lupus nephritis (DPLN).
Th2 cytokines are implicated in the pathogenesis of membranous lupus nephritis (MLN).
Elevated levels of both Th1 and Th2 cytokines are observed in SLE patients, indicating disease complexity.

Conclusions:

The Th1/Th2 cytokine balance is a critical factor determining the specific histopathological subtype of lupus nephritis.
Understanding these distinct immune pathways offers insights into the heterogeneous clinical manifestations and organ involvement in LN.