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Updated: May 29, 2026

Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis
09:28

Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis

Published on: May 12, 2019

Urothelial carcinomas: a focus on human epidermal receptors signaling

Petros D Grivas, Mark Day, Maha Hussain

    American Journal of Translational Research
    |September 10, 2011
    PubMed

    Insights

    Targeted therapies for bladder cancer, focusing on human epidermal growth factor receptors (EGFR and HER2), are under investigation due to chemotherapy plateaus. Identifying biomarkers is crucial for personalized urothelial carcinoma treatment.

    Area of Science:

    • Oncology
    • Molecular Biology
    • Cancer Research

    Background:

    • Bladder cancer is a significant global health concern with limited therapeutic advancements from current chemotherapy.
    • Human epidermal growth factor receptors (EGFR, HER2) are implicated in cancer development and are overexpressed in various solid tumors.
    • Existing data suggest EGFR and HER2 play a role in urothelial carcinoma, necessitating targeted therapy research.

    Purpose of the Study:

    • To investigate the role of human epidermal growth factor receptors (EGFR and HER2) in urothelial carcinoma.
    • To explore the potential of anti-HER targeted therapies for bladder cancer treatment.
    • To highlight the need for identifying prognostic and predictive biomarkers for personalized patient management.

    Main Methods:

    • Review of preclinical and clinical data on EGFR and HER2 in urothelial carcinoma.
    • Analysis of signaling pathway cross-talk involving HER receptors in bladder cancer.
    • Discussion of the complexity in identifying cellular networks within urothelial cancer.

    Main Results:

    • Preclinical and clinical evidence supports the involvement of EGFR and HER2 in urothelial carcinoma.
    • Targeted therapies inhibiting HER signaling are being clinically investigated.
    • Significant cross-talk exists between HER and other signaling pathways in bladder cancer.

    Conclusions:

    • Targeted inhibition of HER-induced signaling pathways shows promise for bladder cancer treatment.
    • Understanding complex cellular networks and signaling pathways is essential for effective urothelial carcinoma therapy.
    • Development of prognostic and predictive biomarkers is critical for personalized bladder cancer management.
    Keywords:
    Bladder cancerEGFRHER2human epidermal receptorstrastuzumaburothelial carcinoma

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