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Related Concept Videos

Immunogold Electron Microscopy01:20

Immunogold Electron Microscopy

Immunoelectron microscopy utilizes immunogold labeling of endogenous proteins with specific antibodies to detect and localize these proteins in cells and tissues. The procedure provides insights into the distribution and quantification of protein under different stimulation conditions offering clues about their functions. Conjugating highly electron-dense gold particles with primary or secondary antibodies allow antigen detection on and within cells, with high resolution and specificity.

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Related Experiment Video

Updated: May 29, 2026

Protein Kinase C-delta Inhibitor Peptide Formulation using Gold Nanoparticles
06:06

Protein Kinase C-delta Inhibitor Peptide Formulation using Gold Nanoparticles

Published on: March 9, 2019

DNA discrete modified gold nanoparticles.

Tao Zhang1, Zhongqiang Yang, Dongsheng Liu

  • 1Key Laboratory of Organic Optoelectronics & Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China.

Nanoscale
|September 10, 2011
PubMed
Summary
This summary is machine-generated.

Precise control over nanoparticle assembly is advancing nanofabrication. DNA discrete modified gold nanoparticles (AuNPs) offer enhanced manipulation for positioning assembly applications.

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Last Updated: May 29, 2026

Protein Kinase C-delta Inhibitor Peptide Formulation using Gold Nanoparticles
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Synthesis of Functionalized 10-nm Polymer-coated Gold Particles for Endothelium Targeting and Drug Delivery
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Synthesis of Functionalized 10-nm Polymer-coated Gold Particles for Endothelium Targeting and Drug Delivery

Published on: January 15, 2018

Area of Science:

  • Nanofabrication
  • Nanoparticle assembly
  • Bioconjugation chemistry

Background:

  • Precise control over self-assembly processes is crucial for advanced nanofabrication.
  • Gold nanoparticles (AuNPs) are versatile building blocks in nanotechnology.
  • DNA modification offers a route to programmable nanoparticle interactions.

Purpose of the Study:

  • To summarize recent advancements in the preparation of DNA discrete modified AuNPs.
  • To review the applications of these modified AuNPs in positioning assembly.
  • To provide insights for improving preparation methods and exploring new applications.

Main Methods:

  • Synthesis of gold nanoparticles (AuNPs).
  • Modification of AuNPs with a countable number of DNA strands (DNA discrete modification).
  • Characterization of DNA-discrete modified AuNPs.
  • Demonstration of positioning assembly using these modified AuNPs.

Main Results:

  • DNA discrete modification enables precise control over AuNP assembly.
  • Various preparation strategies for DNA discrete modified AuNPs have been developed.
  • These modified AuNPs show significant potential in positioning assembly applications.
  • The findings highlight the importance of DNA strand count for assembly control.

Conclusions:

  • DNA discrete modified AuNPs are key components for precise nanofabrication.
  • Further development of preparation strategies will enhance their utility.
  • Positioning assembly with DNA-modified nanoparticles opens new avenues in nanotechnology.