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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
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Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...
Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
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iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.

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Systemic Injection of Neural Stem/Progenitor Cells in Mice with Chronic EAE
09:24

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Published on: April 15, 2014

Cell therapy for multiple sclerosis.

Tamir Ben-Hur1

  • 1Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah-Hebrew University Hospital, Jerusalem 91120, Israel. tamir@hadassah.org.il

Neurotherapeutics : the Journal of the American Society for Experimental Neurotherapeutics
|September 10, 2011
PubMed
Summary
This summary is machine-generated.

Stem cell therapy shows promise for multiple sclerosis (MS) by repairing myelin and reducing autoimmune damage. Further clinical trials are needed to confirm long-term benefits and safety for MS patients.

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Last Updated: May 29, 2026

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09:19

High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies

Published on: January 4, 2015

Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Immunology

Background:

  • Multiple sclerosis (MS) is characterized by progressive neurodegeneration and failure of endogenous repair mechanisms.
  • The potential for repair in the MS brain and the comparative advantage of cell therapy over other strategies remain under investigation.

Purpose of the Study:

  • To explore the potential of cell therapy, particularly stem cell therapy, in addressing the challenges of repair and remyelination in multiple sclerosis.
  • To evaluate the immunomodulatory and neurotrophic properties of stem cells for protecting neural cells and facilitating brain recovery in MS.

Main Methods:

  • Investigating the therapeutic plasticity of neural precursors to replace damaged oligodendrocytes and myelin.
  • Examining the immunomodulatory effects of stem cells delivered via different routes to target affected areas and immune cell trafficking.
  • Reviewing clinical experience with bone marrow stromal (mesenchymal) stem cells in experimental applications for MS.

Main Results:

  • Stem cells possess inherent immunomodulatory and neurotrophic properties beneficial for brain repair.
  • Initial clinical trials suggest the probable safety of intravenous and intrathecal delivery of mesenchymal stem cells in MS patients.
  • Short-term follow-up indicates immunomodulatory effects and clinical benefits, warranting further investigation.

Conclusions:

  • Cell therapy, especially using mesenchymal stem cells, presents a promising avenue for treating multiple sclerosis due to its potential for remyelination and immunomodulation.
  • Further clinical trials are essential to confirm the long-term efficacy, safety, and optimal application of stem cell therapy in MS management.