Ad libitum alcohol ingestion does not induce renal IgA deposition in mice

This study investigated the induction of alcohol abuse related IgA glomerulonephritis in mice, a disease we have previously described in humans and in rats with noncirrhotic alcoholic liver disease. A commercial liquid diet was fed ad libitum to 115 mice from three strains: C57BL/6J, BALB/cJ, and C3H/HeJ. Animals were divided into two groups: 60 received 30% of their caloric intake as ethanol--alcoholized; and 55 were fed the same calorie count in the form of glucose-controls. Mice were killed at weekly intervals after 4 to 10 weeks of liquid diet ingestion. No diagnostic renal pathology was observed.