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DominantMapper: rule-based analysis of SNP data for rapid mapping of dominant diseases in related nuclear families
Ian M Carr1, Colin A Johnson, Alex F Markham
1Leeds Institute of Molecular Medicine, University of Leeds, UK. i.m.carr@leeds.ac.uk
Abstract:
With the advent of cheap rapid methods for whole-genome SNP genotyping and the completion of the Human Genome Project, mapping disease loci has become primarily a bioinformatic rather than a laboratory problem. Here, we describe DominantMapper, a computer program that implements a rule-based analysis algorithm for the detection of dominant disease loci in either a small number of nuclear families or a single large nuclear family. To demonstrate its utility, we present the successful analysis of two pedigrees in which the affected individuals carry either APC or TSPAN12 mutations.
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