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TBX22 and tongue-tie
Tuomas Klockars1, Suvi Kyttänen, Pekka Ellonen
1Department of Otorhinolaryngology, Helsinki University Central Hospital, PL 220, FIN-00029 HUS, Finland. tuomas.klockars@fimnet.fi
Objective:
To resolve if TBX22 mutations cause isolated tongue-tie in the Finnish population.
Design:
Mutation analysis of the coding region of the TBX22 gene in 50 Finnish isolated tongue-tie patients and 61 control samples.
Results:
One putative sequence variation was identified from two male patients, but whether this represents a polymorphism or causative mutation remains unknown.
Conclusions:
Mutations in the coding region of the TBX22 gene are not a major cause of ankyloglossia in the Finnish population and do not explain the sex difference or inheritance of tongue-tie.
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