Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Human Genetics

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...

Gene Therapy

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...

Gene Therapy

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...

Psychosis: Goals of Pharmacotherapy

Psychosis: Goals of Pharmacotherapy

Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation. For...

Treatment Strategies for Psychological Disorders

Treatment Strategies for Psychological Disorders

Treatment approaches for psychological disorders fall into three main categories: psychological, biological, and sociocultural. Each approach targets different aspects of mental health, requiring varying levels of education and training.
Psychological therapies focus on modifying emotions, thoughts, and behaviors through talking, interpreting, listening, rewarding, challenging, and modeling. Clinical psychologists, counselors, and social workers commonly practice psychotherapy. Clinical...

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Efficacy of a Stepped-Care Approach for Adolescents and Adults with Attention-Deficit/Hyperactivity Disorder: An Adaptive Intervention Study Including Randomized Controlled Trials (ESCAlate).

Psychotherapy and psychosomatics·2026

Same author

The link between Wnt-related, stress-related, and circadian genes in the dermal fibroblasts of individuals with attention-deficit hyperactivity disorder.

Journal of neural transmission (Vienna, Austria : 1996)·2025

Same author

Internal consistency of the Mental Health Professional Culture Inventory: A pilot study in Romanian population.

Translational neuroscience·2024

Same author

Transcranial sonography of subcortical structures in tic/tourette disorder.

Journal of psychiatric research·2024

Same author

The Role of Circadian Rhythmicity and CLOCK Genes in Psychiatry.

Pharmacopsychiatry·2023

Same author

Human Derived Dermal Fibroblasts as in Vitro Research Tool to Study Circadian Rhythmicity in Psychiatric Disorders.

Pharmacopsychiatry·2023

Search research articles

Related Experiment Video

Updated: May 29, 2026

A Pipeline using Bilateral In Utero Electroporation to Interrogate Genetic Influences on Rodent Behavior

A Pipeline using Bilateral In Utero Electroporation to Interrogate Genetic Influences on Rodent Behavior

Published on: May 21, 2020

Gene therapy for psychiatric disorders.

Johannes Thome¹, Frank Hässler, Vanna Zachariou

¹Clinic and Policlinic for Psychiatry and Psychotherapy, University of Rostock, Rostock, Germany. johannes.thome@med.uni-rostock.de

The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry

|September 13, 2011

Summary

Gene therapy shows promise for psychiatric disorders in animal models, modifying behavior through molecular interventions. Human application requires overcoming neurobiological, technical, and ethical challenges.

More Related Videos

Focused Ultrasound Induced Blood-Brain Barrier Opening for Targeting Brain Structures and Evaluating Chemogenetic Neuromodulation

Focused Ultrasound Induced Blood-Brain Barrier Opening for Targeting Brain Structures and Evaluating Chemogenetic Neuromodulation

Published on: December 22, 2020

Related Experiment Videos

Last Updated: May 29, 2026

A Pipeline using Bilateral In Utero Electroporation to Interrogate Genetic Influences on Rodent Behavior

A Pipeline using Bilateral In Utero Electroporation to Interrogate Genetic Influences on Rodent Behavior

Published on: May 21, 2020

Focused Ultrasound Induced Blood-Brain Barrier Opening for Targeting Brain Structures and Evaluating Chemogenetic Neuromodulation

Focused Ultrasound Induced Blood-Brain Barrier Opening for Targeting Brain Structures and Evaluating Chemogenetic Neuromodulation

Published on: December 22, 2020

Area of Science:

Neuroscience
Psychiatry
Gene Therapy

Background:

Gene therapy is being explored for psychiatric disorders.
Current research focuses on animal models.

Purpose of the Study:

To review the current status of gene therapy for psychiatric disorders.
To highlight promising developments and challenges.

Main Methods:

Review of experimental neuroscience research.
Analysis of animal models for psychiatric disorders.

Main Results:

Gene therapy approaches show effects in animal models of drug addiction, affective disorders, psychoses, and dementia.
Behavioral parameters are modified via molecular and cellular interventions.

Conclusions:

Gene therapy is not yet applicable to psychiatric patients.
Significant neurobiological, technical, and ethical hurdles must be addressed before human application.