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Updated: May 29, 2026
05:56
Spot Variation Fluorescence Correlation Spectroscopy for Analysis of Molecular Diffusion at the Plasma Membrane of Living Cells
Published on: November 12, 2020
Absorption-dependent apparent volume of distribution at steady state (V(ss)/F) in pharmacokinetic data analysis
1Kimron Veterinary Institute, National Residue Control Laboratory, Beit Dagan, Israel. stefans@moag.gov.il
Journal of Veterinary Pharmacology and Therapeutics
|September 13, 2011
Abstract
No abstract available in PubMed .
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The noncompartmental approach is a widely used method in pharmacokinetics to assess drugs' behaviors in the body. It considers several factors, including clearance, bioavailability, and total volume of distribution.
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01:20Volume of Distribution
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01:25Drug Distribution: Volume of Distribution
The volume of distribution refers to the theoretical volume necessary to contain the entire amount of an administered drug at the same concentration observed in the blood plasma. The body's intracellular fluid compartment, which makes up two-thirds of the total body water, is contrasted with the extracellular fluid compartment—comprising plasma and interstitial fluid—that accounts for one-third. The volume of distribution can vary depending on the characteristics of the drug.
01:05Steady State Concentration
A steady state refers to the level of a drug in the body once it has reached an equilibrium between administration and elimination. It represents the point at which the drug administration rate equals the drug elimination rate, resulting in a relatively constant concentration in the body over time. The dynamic equilibrium is crucial to ensure the drug's effectiveness with minimal risk of toxicity.
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