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Related Experiment Video

Updated: May 29, 2026

Frontal Disconnection for Treating Mild Malformation of Cortical Development with Oligodendroglial Hyperplasia in Epilepsy (MOGHE) in the Frontal Lobe

Frontal Disconnection for Treating Mild Malformation of Cortical Development with Oligodendroglial Hyperplasia in Epilepsy (MOGHE) in the Frontal Lobe

Published on: August 16, 2024

Frontal congenital lipoma.

Carmen Carranza-Romero¹, José C Armario-Hita, José M Fernandez-Vozmediano

¹University Hospital of Puerto Real, University of Cádiz, Cádiz, Spain.

Pediatric Dermatology

|September 13, 2011

Summary

Frontonasal dysplasia (FND) involves facial malformations. A case study suggests congenital midline frontal lipomas in newborns may indicate corpus callosum agenesis, supporting a shared pathogenic mechanism.

Area of Science:

Neuroscience
Genetics
Pediatrics

Background:

Frontonasal dysplasia (FND) is a rare congenital disorder affecting the central face, including the forehead, nose, and philtrum.
FND can present with hypertelorism, occult encephalocele, and nasal clefting, sometimes accompanied by brain and craniofacial abnormalities.
The presence of frontal lipomas or falx cerebri calcification may suggest an underlying lipoma of the corpus callosum.

Observation:

This report details a male neonate with a 15 mm congenital lipoma situated along the medial frontal line.
Magnetic resonance imaging (MRI) revealed complete agenesis of the corpus callosum in the affected infant.
The findings were observed in the context of potential associations between midline craniofacial lipomas and corpus callosum abnormalities.

Findings:

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The case supports a potential link between congenital midline frontal lipomas and agenesis of the corpus callosum.
This observation contributes to the ongoing discussion regarding the pathogenic mechanisms underlying FND and associated midline anomalies.
The study highlights a possible shared etiology for these distinct but potentially related conditions.

Implications:

The findings suggest that imaging of the central nervous system should be considered for newborns presenting with congenital lipomas in the craniofacial midline.
Early identification of corpus callosum agenesis through neuroimaging can facilitate timely intervention and management.
This case underscores the importance of investigating potential central nervous system involvement in neonates with specific craniofacial malformations.