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Chlamydia in canine or feline coronary arteriosclerotic lesions

Ivan C Sostaric-Zuckermann1, Nicole Borel, Carmen Kaiser

  • 1Institute for Veterinary Pathology, University of Zurich, Vetsuisse Faculty, Winterthurerstrasse 268, CH-8057 Zurich, Switzerland. n.borel@access.uzh.ch.

BMC Research Notes
|September 13, 2011
PubMed

Insights

This study found no clear link between Chlamydia infection and coronary arteriosclerosis in dogs or cats. Further research with more samples is needed to confirm these findings on Chlamydia and atherosclerosis.

Area of Science:

  • Veterinary Pathology
  • Infectious Diseases
  • Cardiovascular Science

Background:

  • Chlamydia infection is linked to human coronary atherosclerosis.
  • Data on Chlamydia and atherosclerosis in dogs and cats is limited.
  • This study investigates the correlation in canine and feline species.

Purpose of the Study:

  • To examine the correlation between Chlamydia and spontaneous atherosclerosis/arteriosclerosis in dogs and cats.
  • To investigate the presence of Chlamydiaceae in canine and feline heart tissues with arteriosclerotic lesions.

Main Methods:

  • Histopathological examination of archived canine (n=16) and feline (n=13) heart tissues.
  • Detection of Chlamydiaceae using real-time PCR, ArrayTube Microarray, and immunohistochemistry.
  • Histological classification and grading of arteriosclerotic lesions.

Main Results:

  • All canine cases (atherosclerotic and arteriosclerotic) were negative for Chlamydia.
  • One feline arteriosclerotic case tested positive for Chlamydia abortus.
  • Canine and feline arteriosclerotic lesions were similar, predominantly moderate and hyperplastic.

Conclusions:

  • No obvious correlation found between canine/feline coronary arteriosclerosis and Chlamydia.
  • Further studies with larger sample sizes are required to definitively conclude the Chlamydia-atherosclerosis link in dogs.
Abstract

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