Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acute Kidney Injury VI: Nursing Management01:22

Acute Kidney Injury VI: Nursing Management

Acute Kidney Injury (AKI) results in an inability to maintain fluid, electrolyte, and acid-base balance. Effective nursing management is critical in improving patient outcomes and includes comprehensive patient assessment and targeted interventions.Comprehensive Patient AssessmentA detailed history collection is essential, focusing on any recent infections, nephrotoxic medication use, or chronic conditions such as hypertension and diabetes that may contribute to AKI. During the physical...
Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
Pneumonia IV: Management01:28

Pneumonia IV: Management

The treatment of pneumonia varies based on its severity and the causative pathogen. Here is a structured approach to managing pneumonia, integrating pharmaceutical and supportive care strategies.
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
Endocarditis IV: Nursing Management01:29

Endocarditis IV: Nursing Management

Infective endocarditis (IE) is a chronic infection of the heart's endocardium, primarily affecting the heart valves. A detailed nursing assessment for a patient with IE involves collecting subjective and objective data to ensure an accurate diagnosis and timely intervention.Subjective DataThe nurse gathers information about the patient's symptoms and complaints during the subjective assessment. Patients with infective endocarditis often report non-specific symptoms that can mimic other...
Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cancer Metabolism as a Therapeutic Target and Review of Interventions.

Nutrients·2023
Same author

"MATH+" Multi-Modal Hospital Treatment Protocol for COVID-19 Infection: Clinical and Scientific Rationale.

Journal of clinical medicine research·2022
Same author

A scoping review of the pathophysiology of COVID-19.

International journal of immunopathology and pharmacology·2021
Same author

Ivermectin, A Reanalysis of the Data.

American journal of therapeutics·2021
Same author

The Ichikado CT score as a prognostic tool for coronavirus disease 2019 pneumonia: a retrospective cohort study.

Journal of intensive care·2021
Same author

Review of the Emerging Evidence Demonstrating the Efficacy of Ivermectin in the Prophylaxis and Treatment of COVID-19.

American journal of therapeutics·2021
Same journal

Response letter to "Venovenous extracorporeal membrane oxygenation initiation and reduction in vasopressor requirements".

Annals of intensive care·2026
Same journal

Impact of Respiratory Effort Parameters on Clinical Outcomes in Respiratory Failure Patients (Effort-I): A Prospective Observational Study.

Annals of intensive care·2026
Same journal

Human Development Index and outcomes in older critically ill patients: A European multicentre study.

Annals of intensive care·2026
Same journal

Impact of gender on how intensive care medicine residents experience their medical studies and training and perceive their specialty: a national survey.

Annals of intensive care·2026
Same journal

Diagnosis and management of Children with Post-Intensive Care Syndrome in Paediatrics: Clinical Practice Guidelines by the French National Authority for Health (HAS).

Annals of intensive care·2026
Same journal

Is arterial hypotension the real enemy in septic shock or is it just cosmetic?

Annals of intensive care·2026
See all related articles

Related Experiment Video

Updated: May 29, 2026

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
07:30

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Published on: June 15, 2019

Surviving sepsis: going beyond the guidelines.

Paul E Marik1

  • 1Division of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School, Norfolk, VA 23507, USA. marikpe@evms.edu.

Annals of Intensive Care
|September 13, 2011
PubMed
Summary
This summary is machine-generated.

The Surviving Sepsis Campaign guidelines, while widely adopted, lack strong evidence. This review questions the 6-hour bundle

Related Experiment Videos

Last Updated: May 29, 2026

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
07:30

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Published on: June 15, 2019

Area of Science:

  • Critical Care Medicine
  • Infectious Diseases
  • Emergency Medicine

Background:

  • The Surviving Sepsis Campaign (SSC) provides global guidelines for severe sepsis and septic shock management.
  • Previous SSC guidelines were published in 2004 and updated in 2008.
  • These guidelines are considered a standard of care but are largely not evidence-based.

Purpose of the Study:

  • To review the validity of the SSC 6-hour bundle.
  • To propose a more evidence-based approach for initial resuscitation in severe sepsis.

Main Methods:

  • Critical review of the evidence supporting the SSC 6-hour bundle.
  • Analysis of the validity of the single-center study underpinning the bundle's major components.

Main Results:

  • Most SSC guideline recommendations are not evidence-based.
  • The validity of the key study for the 6-hour bundle is under scrutiny.
  • Current guidelines may not represent the optimal standard of care.

Conclusions:

  • The evidence base for the SSC 6-hour bundle requires re-evaluation.
  • An evidence-based approach is needed for initial severe sepsis resuscitation.
  • Clinical practice may need to shift from current SSC recommendations.