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Related Concept Videos

Introduction to Innate and Adaptive Immunity01:21

Introduction to Innate and Adaptive Immunity

The human immune system is a complex defense mechanism that protects the body from harmful pathogens and foreign substances. It comprises two crucial components: innate and adaptive immunity.
Innate immunity is the body's natural, nonspecific defense system that acts quickly to protect against pathogens. It incorporates physical barriers like skin and mucous membranes and cellular elements such as phagocytes and natural killer cells. This part of our immune system provides an immediate,...
Defense Mechanism Against Infection01:26

Defense Mechanism Against Infection

Natural flora, body system defenses, and inflammation are natural barriers of the body against infectious agents regardless of previous exposure. Normal floras of the human body refer to the microbial population that colonizes the skin and mucous membranes.
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
What is the Immune System?01:38

What is the Immune System?

Overview
Acute Inflammation I: Inflammatory Response01:26

Acute Inflammation I: Inflammatory Response

Acute inflammation is a rapid, short-lived physiological response to tissue injury or infection, designed to eliminate harmful agents and initiate repair. This tightly regulated process typically lasts from minutes to several days and is triggered by factors such as microbial invasion, physical trauma, or chemical injury.Recognition and Mediator ReleaseThe inflammatory response begins when resident immune cells—such as mast cells, macrophages, and dendritic cells—detect damage-associated...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

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Related Experiment Video

Updated: May 29, 2026

Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System
10:25

Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System

Published on: September 20, 2019

[Atopic dermatitis, innate immunity, and infection].

Cristina Lopes1, Ana Filipa Duarte, Osvaldo Correia

  • 1Serviço e Laboratório de Imunologia Faculdade de Medicina, Universidade do Porto, Portugal.

Dermatology Online Journal
|September 13, 2011
PubMed
Summary

Atopic dermatitis prevalence is rising, impacting quality of life. This review covers skin barrier and immune dysfunction, offering insights for managing flares and infections.

Related Experiment Videos

Last Updated: May 29, 2026

Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System
10:25

Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System

Published on: September 20, 2019

Area of Science:

  • Immunology
  • Dermatology
  • Microbiology

Context:

  • Rising prevalence of atopic dermatitis in Western societies.
  • Significant impact on patient and family quality of life.
  • Complex pathophysiology involving immune system dysregulation.

Purpose:

  • Provide an up-to-date review of atopic dermatitis pathophysiology.
  • Highlight clinical implications of skin barrier dysfunction.
  • Discuss immunological deregulation in atopic dermatitis.

Summary:

  • Recent insights into innate and adaptive immunity dysfunction.
  • Increased predisposition to colonization/infection with specific microorganisms.
  • Focus on skin barrier defects and immune dysregulation.

Impact:

  • Offers a useful approach for handling exacerbations.
  • Provides guidance for managing infectious events in atopic dermatitis.
  • Enhances understanding of atopic dermatitis for clinicians and researchers.