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Updated: May 29, 2026

Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery
12:04

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Published on: January 6, 2011

Surgery for tardive dyskinesia.

Stéphane Thobois1, Alice Poisson, Philippe Damier

  • 1Université Lyon I; Hospices Civils de Lyon, Hôpital Neurologique Pierre Wertheimer, service de Neurologie C, Lyon, France.

International Review of Neurobiology
|September 13, 2011
PubMed
Summary
This summary is machine-generated.

Tardive dyskinesia (TD) treatment remains challenging. Deep brain stimulation of the internal globus pallidus shows significant improvement in motor symptoms without adverse psychiatric effects.

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Area of Science:

  • Neurology
  • Neurosurgery
  • Psychiatry

Background:

  • Tardive dyskinesia (TD) is a frequent and distressing adverse effect of antipsychotic medications.
  • Current medical treatments for TD often yield suboptimal results.

Purpose of the Study:

  • To evaluate the efficacy of surgical interventions for tardive dyskinesia.
  • To assess the impact of deep brain stimulation (DBS) on motor and psychiatric symptoms in TD patients.

Main Methods:

  • Review of case reports on lesioning surgeries (pallidotomy, thalamotomy).
  • Analysis of multiple series, including a controlled study, on deep brain stimulation of the internal globus pallidus for TD.

Main Results:

  • Lesioning surgeries have shown limited but suggestive efficacy in case reports.
  • Deep brain stimulation of the internal globus pallidus demonstrated marked improvement in motor symptoms.
  • No significant psychiatric side effects were observed with DBS treatment.

Conclusions:

  • Deep brain stimulation of the internal globus pallidus is a promising therapeutic option for tardive dyskinesia.
  • DBS offers significant motor symptom relief with a favorable psychiatric safety profile.