Basic therapy of rheumatoid arthritis: nonsteroidal anti-inflammatory drugs

Aspirin is recommended for initial therapy of RA. If aspirin is not tolerated, an NSAID is recommended. The choice of NSAID should be based on cost, convenience, safety, and the personal experience of the physician. An adequate trial of at least 2 weeks should be completed before changing to another NSAID. Therapy should be closely monitored for adverse reactions, particularly renal and gastrointestinal effects.