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The effects of high- and low-dose aspirin on thermoregulation during and after acute cold exposure
Leigh K Murray1, Ronald Otterstetter, Matthew D Muller
1Walsh University, North Canton, OH 44720, USA. Lmurray@walsh.edu
Objective:
To explore the effect of aspirin on the thermoregulatory responses of men during exposure to 12°C air (acute cold exposure) for a period of 120 minutes and recovery in 25°C air (rewarming) for 120 minutes.
Methods:
Seven male subjects (26.1 ± 2.4 yr) underwent pre-experimental testing to determine peak VO(2) and body composition. Participants underwent 3 trials in which they ingested the following for 1 week prior to each experimental trial: a capsule filled with cellulose (placebo), 81 mg · day(-1) of aspirin (low-dose aspirin), or 650 mg · day(-1) of aspirin (high-dose aspirin). Each trial consisted of a 30-minute baseline period, 120 minutes of exposure to 12°C air, and 120 minutes of recovery in 25°C air. Mean skin temperature and rectal temperature (T(re)) were measured, and heat production was calculated.
Results:
During both acute cold exposure and rewarming, analysis of variance revealed a main effect for time (P < .05) with respect to T(re), mean skin temperature, and heat production. However, there were no significant differences between the treatments or treatment by time interactions.
Conclusions:
These data demonstrate that aspirin had no significant effect on the thermal and metabolic responses during acute cold exposure and rewarming.
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