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Etanercept-induced encephalopathy in a 7-year-old child

Barış Ekici1, Kubilay Aydın, Serdar Cantez

  • 1Department of Pediatric Neurology, Istanbul Medical Faculty, Istanbul University, Fatih, Istanbul, Turkey. ekicibaris@yahoo.com

Pediatric Neurology
|September 13, 2011
PubMed

Insights

Etanercept can cause serious adverse events, including encephalopathy. This report details the first pediatric case of etanercept-related encephalopathy in a child with systemic arthritis.

Area of Science:

  • Immunology
  • Neurology
  • Pediatrics

Background:

  • Etanercept is a biologic therapy used for autoimmune diseases.
  • Known adverse events include infections, malignancies, and neurological disorders.
  • Encephalopathy is a rare but serious side effect.

Observation:

  • A 7-year-old patient with systemic arthritis received etanercept.
  • The patient developed encephalopathy shortly after the third dose.
  • This is the first reported pediatric case of its kind.

Findings:

  • The patient experienced encephalopathy following etanercept treatment.
  • This adverse event occurred in a pediatric patient with systemic arthritis.
  • The temporal association suggests a link between etanercept and encephalopathy.

Implications:

  • Highlights the potential for severe neurological adverse events in pediatric patients treated with etanercept.
  • Underscores the need for vigilant monitoring for encephalopathy in children receiving this medication.
  • Contributes to the understanding of rare side effects of biologic therapies in pediatric rheumatology.

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