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Published on: April 9, 2014
HIV Therapy Simulator: a graphical user interface for comparing the effectiveness of novel therapy regimens
Huat Chye Lim1, Marcel E Curlin, John E Mittler
1Department of Microbiology, University of Washington, Seattle, WA 98195, USA.
Unlabelled:
Computer simulation models can be useful in exploring the efficacy of HIV therapy regimens in preventing the evolution of drug-resistant viruses. Current modeling programs, however, were designed by researchers with expertise in computational biology, limiting their accessibility to those who might lack such a background. We have developed a user-friendly graphical program, HIV Therapy Simulator (HIVSIM), that is accessible to non-technical users. The program allows clinicians and researchers to explore the effectiveness of various therapeutic strategies, such as structured treatment interruptions, booster therapies and induction-maintenance therapies. We anticipate that HIVSIM will be useful for evaluating novel drug-based treatment concepts in clinical research, and as an educational tool.
Availability:
HIV Therapy Simulator is freely available for Mac OS and Windows at http://sites.google.com/site/hivsimulator/.
Contact:
jmittler@uw.edu.
Supplementary Information:
Supplementary data are available at Bioinformatics online.
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