Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Reticular Dermis01:15

Reticular Dermis

The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
The Extracellular Matrix01:29

The Extracellular Matrix

Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
The Extracellular Matrix01:42

The Extracellular Matrix

Overview
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Extracellular Matrix01:26

Extracellular Matrix

Unlike epithelial tissue, which is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. This extracellular matrix (ECM) is composed of fibrous proteins like collagen, elastin, and fibronectin in a ground substance consisting of interstitial fluid, cell adhesion proteins, and proteoglycans. The proteoglycans form a gel-like material in the spaces between cells and provide hydration, buffering, binding, and force...
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Harry J. Buncke to M. Gazi Yaşargil: a historical lesson in cross-specialty microsurgical innovation.

Journal of neurosurgery·2026
Same author

Intraoperative Versus Postoperative Correction of Vascular Compromise: Comparison of Flap and Patient Outcomes in Free Flap Breast Reconstruction.

Journal of reconstructive microsurgery·2026
Same author

The Orthoplastic Approach.

Clinics in plastic surgery·2026
Same author

Bone Flaps for Structural Reconstruction of the Lower Extremity.

Clinics in plastic surgery·2026
Same author

Mohs-facilitated excision: A case series of a multidisciplinary approach to reduce local recurrence of advanced keratinocyte carcinomas.

Journal of the American Academy of Dermatology·2026
Same author

The Other Side: Outcomes of the Nonradiated Breast in Bilateral Reconstruction With Unilateral Postmastectomy Radiation Therapy.

Annals of plastic surgery·2026

Related Experiment Video

Updated: May 29, 2026

Improving 2D and 3D Skin In Vitro Models Using Macromolecular Crowding
09:14

Improving 2D and 3D Skin In Vitro Models Using Macromolecular Crowding

Published on: August 22, 2016

Acellular dermal matrix: general principles for the plastic surgeon.

Joshua Fosnot1, Stephen J Kovach, Joseph M Serletti

  • 1Division of Plastic Surgery, University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA. joshua.fosnot@uphs.upenn.edu

Aesthetic Surgery Journal
|September 13, 2011
PubMed
Summary

Acellular dermal matrix (ADM) is a biologically-derived product with expanding applications in plastic surgery. This overview summarizes ADM

More Related Videos

Engineering a Bilayered Hydrogel to Control ASC Differentiation
07:48

Engineering a Bilayered Hydrogel to Control ASC Differentiation

Published on: May 25, 2012

Tissue Engineering of Tumor Stromal Microenvironment with Application to Cancer Cell Invasion
05:48

Tissue Engineering of Tumor Stromal Microenvironment with Application to Cancer Cell Invasion

Published on: March 18, 2014

Related Experiment Videos

Last Updated: May 29, 2026

Improving 2D and 3D Skin In Vitro Models Using Macromolecular Crowding
09:14

Improving 2D and 3D Skin In Vitro Models Using Macromolecular Crowding

Published on: August 22, 2016

Engineering a Bilayered Hydrogel to Control ASC Differentiation
07:48

Engineering a Bilayered Hydrogel to Control ASC Differentiation

Published on: May 25, 2012

Tissue Engineering of Tumor Stromal Microenvironment with Application to Cancer Cell Invasion
05:48

Tissue Engineering of Tumor Stromal Microenvironment with Application to Cancer Cell Invasion

Published on: March 18, 2014

Area of Science:

  • Plastic Surgery
  • Biomaterials
  • Regenerative Medicine

Background:

  • Acellular dermal matrix (ADM) is a biologically-derived material gaining traction in plastic surgery.
  • Its use has grown significantly, accompanied by a surge in scientific literature over the last decade.
  • ADM offers potential solutions for complex reconstructive and cosmetic challenges.

Purpose of the Study:

  • To provide a comprehensive overview of Acellular dermal matrix (ADM).
  • To summarize the current body of literature on ADM.
  • To clarify the biology, applications, and research surrounding ADM.

Main Methods:

  • Literature review and synthesis.
  • Analysis of existing research on ADM.
  • General overview of biological properties and surgical applications.

Main Results:

  • ADM has demonstrated promising outcomes in various plastic surgery procedures.
  • The scientific literature on ADM has expanded considerably.
  • ADM shows potential for addressing challenging surgical problems.

Conclusions:

  • Acellular dermal matrix (ADM) is a versatile biomaterial with significant potential in plastic surgery.
  • Further research and application of ADM are supported by a growing evidence base.
  • This overview serves as a foundation for understanding ADM's role in cosmetic and reconstructive surgery.