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Related Concept Videos

Reticular Dermis01:15

Reticular Dermis

The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
Extracellular Matrix01:26

Extracellular Matrix

Unlike epithelial tissue, which is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. This extracellular matrix (ECM) is composed of fibrous proteins like collagen, elastin, and fibronectin in a ground substance consisting of interstitial fluid, cell adhesion proteins, and proteoglycans. The proteoglycans form a gel-like material in the spaces between cells and provide hydration, buffering, binding, and force...
The Extracellular Matrix01:42

The Extracellular Matrix

Overview
The Extracellular Matrix01:29

The Extracellular Matrix

Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
Phases of Wound Repair01:28

Phases of Wound Repair

Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...

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Related Experiment Video

Updated: May 29, 2026

A Case Series of Successful Abdominal Closure Utilizing a Novel Technique Combining a Mechanical Closure System with a Biologic Xenograft that Accelerates Wound Healing
20:33

A Case Series of Successful Abdominal Closure Utilizing a Novel Technique Combining a Mechanical Closure System with a Biologic Xenograft that Accelerates Wound Healing

Published on: July 4, 2019

Acellular dermal matrix in abdominal wall reconstruction.

Ronald P Silverman1

  • 1Division of Plastic Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA. rsilverman@smail.umaryland.edu

Aesthetic Surgery Journal
|September 13, 2011
PubMed
Summary

Acellular dermal matrices (ADM) provide a biologic alternative for abdominal wall reconstruction when synthetic mesh is risky. This review covers ADM

Area of Science:

  • Surgical Innovation
  • Biomaterials Science
  • Regenerative Medicine

Background:

  • Abdominal wall reconstruction is complex, often requiring prosthetic mesh.
  • Synthetic mesh carries risks of infection and recurrence in contaminated fields.
  • Acellular dermal matrices (ADM) present a biologic option for hernia repair.

Purpose of the Study:

  • To review the evolution of ventral hernia repair techniques.
  • To explain the biological basis of ADM in abdominal wall reconstruction.
  • To describe current ADM applications, including indications, methods, benefits, and limitations.

Main Methods:

  • Historical review of surgical techniques for ventral hernia repair.
  • Explanation of ADM biology and integration in tissue repair.

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Tissue Engineering of Tumor Stromal Microenvironment with Application to Cancer Cell Invasion

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08:02

Fabrication of Decellularized Cartilage-derived Matrix Scaffolds

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Last Updated: May 29, 2026

A Case Series of Successful Abdominal Closure Utilizing a Novel Technique Combining a Mechanical Closure System with a Biologic Xenograft that Accelerates Wound Healing
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  • Analysis of clinical data on ADM use in abdominal wall reconstruction.

    • Main Results:

    • ADM has evolved as a viable alternative to synthetic mesh in specific scenarios.
    • Understanding ADM biology is key to optimizing its application.
    • Current literature details ADM's indications, techniques, benefits, and drawbacks.

    Conclusions:

    • Acellular dermal matrices offer a promising biologic solution for complex abdominal wall reconstruction.
    • ADM's role is expanding, particularly in contaminated or high-risk cases.
    • Further research can refine ADM techniques and outcomes in hernia repair.