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Related Concept Videos

Reticular Dermis01:15

Reticular Dermis

The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
Phases of Wound Repair01:28

Phases of Wound Repair

Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
Extracellular Matrix01:26

Extracellular Matrix

Unlike epithelial tissue, which is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. This extracellular matrix (ECM) is composed of fibrous proteins like collagen, elastin, and fibronectin in a ground substance consisting of interstitial fluid, cell adhesion proteins, and proteoglycans. The proteoglycans form a gel-like material in the spaces between cells and provide hydration, buffering, binding, and force...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
The Extracellular Matrix01:42

The Extracellular Matrix

Overview
The Extracellular Matrix01:29

The Extracellular Matrix

Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...

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Tissue Engineering of Tumor Stromal Microenvironment with Application to Cancer Cell Invasion
05:48

Tissue Engineering of Tumor Stromal Microenvironment with Application to Cancer Cell Invasion

Published on: March 18, 2014

Acellular dermal matrix in primary breast reconstruction.

Hani Sbitany1, Howard N Langstein

  • 1Division of Plastic Surgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. Hani.Sbitany@gmail.com

Aesthetic Surgery Journal
|September 13, 2011
PubMed
Summary

Acellular dermal matrix (ADM) enhances breast reconstruction outcomes. This review summarizes ADM literature for primary implant reconstruction, highlighting benefits and future research needs.

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Area of Science:

  • Plastic Surgery
  • Regenerative Medicine
  • Biomaterials

Background:

  • Acellular dermal matrix (ADM) use is rising in plastic surgery.
  • ADM offers a novel approach for breast reconstruction.
  • Standard expander/implant techniques are effective, but ADM provides enhanced predictability.

Purpose of the Study:

  • To review existing literature on acellular dermal matrix (ADM) for primary breast reconstruction.
  • To elucidate the benefits of ADM in single- and two-stage breast reconstruction.
  • To identify areas requiring further research regarding ADM in breast reconstruction.

Main Methods:

  • Literature review of studies on acellular dermal matrix (ADM) in breast reconstruction.
  • Synthesis of data on ADM's role in primary implant-based breast reconstruction.
  • Analysis of outcomes in single- and two-stage reconstruction protocols.

Main Results:

  • ADM has become a valuable tool in breast reconstruction.
  • ADM contributes to lasting and predictable results.
  • Evidence supports ADM's efficacy in various reconstruction stages.

Conclusions:

  • Acellular dermal matrix (ADM) is a significant advancement in breast reconstruction.
  • Further investigation is needed to fully optimize ADM applications.
  • ADM offers improved outcomes for patients undergoing implant-based breast reconstruction.