Related Experiment Video

Updated: May 29, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Endostatin and vascular endothelial growth factor: potential regulators of endothelial progenitor cell number in

Ewa Wątorek1, Maria Paprocka, Danuta Duś

  • 1Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Wrocław, Poland. ewatorek@wp.pl

Polskie Archiwum Medycyny Wewnetrznej
|September 13, 2011
PubMed

Insights

Patients with chronic kidney disease (CKD) have fewer circulating endothelial progenitor cells (EPCs), potentially impairing vascular repair and increasing cardiovascular risk. Elevated endostatin levels in CKD patients warrant further study.

Area of Science:

  • Nephrology
  • Cardiology
  • Vascular Biology

Background:

  • Chronic kidney disease (CKD) is linked to increased cardiovascular mortality.
  • Circulating endothelial progenitor cells (EPCs) are crucial for vascular repair.
  • Reduced EPCs may contribute to heightened cardiovascular risk in CKD patients.

Purpose of the Study:

  • To quantify circulating EPCs in CKD patients.
  • To investigate the relationship between EPCs and factors like VEGF and endostatin.
  • To explore the impact of renal impairment severity on EPC levels.

Main Methods:

  • Study included 139 patients with varying CKD severity (predialysis, hemodialysis, peritoneal dialysis).
  • Plasma levels of vascular endothelial growth factor (VEGF) and endostatin were measured using ELISA.
  • Circulating EPCs (CD34+VEGFR2+) were quantified via flow cytometry.

Main Results:

  • A positive correlation was found between VEGF, EPCs (CD34+VEGFR2+), and glomerular filtration rate.
  • Endostatin levels progressively increased with renal impairment, highest in hemodialysis and peritoneal dialysis groups.
  • EPC counts were significantly reduced in predialysis and hemodialysis CKD patients compared to controls.

Conclusions:

  • Decreased circulating EPCs in CKD patients may compromise vascular regeneration, elevating cardiovascular risk.
  • Elevated endostatin levels in CKD warrant further investigation into their effects on endothelial function and progenitor cells.
Abstract

More Related Videos

Decellularization and Recellularization Methodology for Human Saphenous Veins11:35

Decellularization and Recellularization Methodology for Human Saphenous Veins

Published on: July 27, 2018

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery08:43

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery

Published on: February 14, 2017

Related Concept Videos

Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...