Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Cancer Vaccines

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...

Immune Surveillance by NK Cells and Phagocytes

Immune Surveillance by NK Cells and Phagocytes

Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Improving protein secretion in yeasts: From secretion leader engineering and AI-driven prediction to bioprocess performance.

Bioresource technology·2026

Same author

Antibodies against interleukin-10 receptor reduce IL-6 and TNF-α levels and increase TGF-β levels in patients with severe fever with thrombocytopenia syndrome virus and SARS-CoV-2 infection.

Frontiers in immunology·2026

Same author

IL-27-mediated hematopoietic dysregulation exacerbates disease severity in severe fever with thrombocytopenia syndrome virus infection.

Science translational medicine·2026

Same author

Quantitative phantom-based comparison of commercial CT metal artifact reduction algorithms.

Journal of applied clinical medical physics·2026

Same author

Immunopathogenic insights into members of the class Bunyaviricetes: a comparative review of emerging zoonotic threats.

Current opinion in virology·2026

Same author

Adaptive optimization framework for accurate multi-material decomposition in dual-energy CT.

Biomedical physics & engineering express·2026

Search research articles

Related Experiment Video

Updated: May 29, 2026

Preparation of Tumor Antigen-loaded Mature Dendritic Cells for Immunotherapy

Preparation of Tumor Antigen-loaded Mature Dendritic Cells for Immunotherapy

Published on: August 1, 2013

A multifunctional core-shell nanoparticle for dendritic cell-based cancer immunotherapy.

Nam-Hyuk Cho¹, Taek-Chin Cheong, Ji Hyun Min

¹Department of Microbiology and Immunology, Seoul National University College of Medicine and Institute of Endemic Diseases, Seoul National University Medical Research Center, Seoul, Republic of Korea.

Nature Nanotechnology

|September 13, 2011

Summary

This study introduces novel iron oxide-zinc oxide nanoparticles for delivering cancer antigens to dendritic cells. These nanoparticles enable simultaneous imaging and enhance anti-tumour immune responses in mice.

More Related Videos

Chemical Conjugation of a Purified DEC-205-Directed Antibody with Full-Length Protein for Targeting Mouse Dendritic Cells In Vitro and In Vivo

Chemical Conjugation of a Purified DEC-205-Directed Antibody with Full-Length Protein for Targeting Mouse Dendritic Cells In Vitro and In Vivo

Published on: February 5, 2021

Tractable In Vivo Reprogramming of Tumor Cells to Type 1 Conventional Dendritic Cell-like Cells

Tractable In Vivo Reprogramming of Tumor Cells to Type 1 Conventional Dendritic Cell-like Cells

Published on: August 1, 2025

Related Experiment Videos

Last Updated: May 29, 2026

Preparation of Tumor Antigen-loaded Mature Dendritic Cells for Immunotherapy

Preparation of Tumor Antigen-loaded Mature Dendritic Cells for Immunotherapy

Published on: August 1, 2013

Chemical Conjugation of a Purified DEC-205-Directed Antibody with Full-Length Protein for Targeting Mouse Dendritic Cells In Vitro and In Vivo

Chemical Conjugation of a Purified DEC-205-Directed Antibody with Full-Length Protein for Targeting Mouse Dendritic Cells In Vitro and In Vivo

Published on: February 5, 2021

Tractable In Vivo Reprogramming of Tumor Cells to Type 1 Conventional Dendritic Cell-like Cells

Tractable In Vivo Reprogramming of Tumor Cells to Type 1 Conventional Dendritic Cell-like Cells

Published on: August 1, 2025

Area of Science:

Biomedical Engineering
Immunology
Nanotechnology

Background:

Dendritic cell (DC)-based cancer immunotherapy needs efficient tumour antigen delivery and in vivo migration monitoring.
Current nanoparticle applications for antigen delivery are limited by solvent toxicity and transfection agent requirements.

Purpose of the Study:

To develop a novel nanoparticle system for efficient antigen delivery to DCs and simultaneous in vivo imaging.
To evaluate the efficacy of this nanoparticle-DC complex in stimulating anti-tumour immune responses.

Main Methods:

Fabrication of iron oxide-zinc oxide core-shell nanoparticles.
Complexation of nanoparticles with carcinoembryonic antigen (CEA).
In vitro uptake studies in dendritic cells and in vivo imaging using magnetic resonance imaging (MRI).
Assessment of T-cell responses, tumour growth, and survival in immunized mice.

Main Results:

The iron oxide-zinc oxide nanoparticle efficiently delivered CEA into dendritic cells within one hour.
Nanoparticle-antigen complex uptake was confirmed by confocal microscopy (in vitro) and MRI (in vivo).
Mice immunized with nanoparticle-loaded DCs exhibited enhanced CEA-specific T-cell responses, delayed tumour growth, and improved survival.

Conclusions:

Iron oxide-zinc oxide core-shell nanoparticles serve as effective carriers for dendritic cell-based cancer immunotherapy.
These nanoparticles facilitate antigen delivery, DC uptake, and in vivo imaging, leading to improved anti-tumour efficacy.
This approach offers a promising strategy for developing advanced cancer vaccines.