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Mutagenicity of systemic organophosphate pesticides metasystox and rogor
S S Ladhar1, I S Grover, S K Randhawa
1School of Life Sciences, Guru Nanak Dev University, Amritsar, India.
Indian Journal of Experimental Biology
|April 1, 1990
Abstract:
Mutagenicity of metasystox and rogor could not be detected on the basis of tests employing Ames Salmonella/microsome assay even in the presence of wheat seedling or rat liver microsomal activation systems.
Insights
Metasystox and Rogor showed no mutagenicity in Ames Salmonella/microsome assays. These tests included wheat seedling and rat liver activation systems, indicating a lack of genotoxic potential.
Area of Science:
- Environmental toxicology
- Chemical safety assessment
Background:
- Pesticides like Metasystox and Rogor are widely used in agriculture.
- Assessing the mutagenicity of such chemicals is crucial for environmental and human health risk evaluation.
Purpose of the Study:
- To evaluate the mutagenic potential of Metasystox and Rogor.
- To determine if metabolic activation influences the mutagenicity of these pesticides.
Main Methods:
- The Ames Salmonella/microsome assay was employed.
- Tests were conducted with and without wheat seedling activation systems.
- Tests were also performed with rat liver microsomal activation systems.
Main Results:
- No mutagenic activity was detected for Metasystox.
- No mutagenic activity was detected for Rogor.
- Activation systems did not induce mutagenicity for either compound.
Conclusions:
- Metasystox and Rogor do not appear to be mutagenic based on the Ames test.
- The tested activation systems did not reveal any latent genotoxic effects of these pesticides.