Related Experiment Video
Updated: May 29, 2026
08:57
Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
Published on: May 17, 2024
A case of myxoid dermatofibrosarcoma protuberans
Yeon Ju Hong1, You Won Choi, Ki Bum Myung
1Department of Dermatology, School of Medicine, Ewha Womans University, Seoul, Korea.
Annals of Dermatology
|September 13, 2011
Summary
This case report details a rare myxoid variant of dermatofibrosarcoma protuberans (DFSP), a slow-growing skin tumor. The findings highlight characteristic histopathology and CD34 positivity in this uncommon presentation.
Area of Science:
- Dermatopathology
- Oncology
Background:
- Dermatofibrosarcoma protuberans (DFSP) is a rare, slow-growing malignant neoplasm originating in the dermis.
- The myxoid variant of DFSP is exceptionally rare and characterized by significant myxoid degeneration within the tumor stroma.
Observation:
- A case of a 69-year-old woman presenting with a multinodular reddish plaque on her trunk.
- Histopathological examination revealed a dermal tumor composed of uniform spindle cells with a storiform pattern and prominent myxoid stromal changes.
Findings:
- Immunohistochemical analysis showed tumor cells were strongly positive for CD34.
- The tumor cells were negative for S-100 and desmin, aiding in differential diagnosis.
Implications:
- This report contributes to the limited literature on myxoid DFSP, emphasizing its distinct histopathological features.
- Accurate diagnosis of myxoid DFSP is crucial for appropriate patient management and prognosis.
