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Involvement of endothelin in renal processes
S Cornet1, A Braillon, C Guilmard
1Institut Henri Beaufour Research Labs, ZA de Courtaboeuf, Les Ulis, Clichy, France.
Hypertension (Dallas, Tex. : 1979)
|June 1, 1990
Summary
Endothelin causes immediate low blood pressure and reduced blood flow, followed by a significant blood pressure increase. This peptide strongly constricts renal blood vessels, increasing protein in urine.
Area of Science:
- Cardiovascular Physiology
- Renal Physiology
Background:
- Endothelin is a potent vasoconstrictor peptide.
- Its effects on regional hemodynamics and renal function require detailed investigation.
Purpose of the Study:
- To investigate the dose-dependent effects of endothelin on regional hemodynamics and renal function in conscious rats.
Main Methods:
- Chronic instrumentation of rats with catheters and Doppler flow probes.
- Administration of varying doses of endothelin (0.2-2 nmol/kg).
- Measurement of mean arterial pressure, regional blood flows, vascular resistance, and proteinuria.
Main Results:
- Endothelin induced a biphasic mean arterial pressure response: initial hypotension followed by hypertension.
- Significant dose-dependent vasoconstriction in renal and mesenteric beds, with renal effects being more pronounced.
- Increased proteinuria and albumin excretion at higher endothelin doses.
Conclusions:
- The renal vascular bed is highly sensitive to endothelin's vasoconstrictive effects.
- Endothelin significantly impacts renal hemodynamics and function, leading to proteinuria.