Related Experiment Video
Updated: May 29, 2026

Experimental Protocol for Using Drosophila As an Invertebrate Model System for Toxicity Testing in the Laboratory
Published on: July 10, 2018
A linear model to predict chronic effects of chemicals on Daphnia magna
Enrico Mombelli1, Alexandre R R Pery
1Unité Modèles Pour l'Ecotoxicologie et la Toxicologie (METO), Institut National de l'Environnement Industriel et des Risques (INERIS), Verneuil en Halatte, France. enrico.mombelli@ineris.fr
Abstract:
Chronic toxicity data for Daphnia magna are information requirements in the context of regulations on chemical safety. This paper proposes a linear model for the prediction of chemically-induced effects on the reproductive output of D. magna. This model is based on data retrieved from the Japanese Ministry of Environment database and it predicts chronic effects as a function of acute toxicity data. The proposed model proved to be able to predict chronic toxicities for chemicals not used in the training set. Our results suggest that experiments involving chronic exposure to chemicals could be reduced thanks to the proposed model.
Related Concept Videos
Pharmacodynamic Models: Linear Concentration–Effect Model
Mechanistic Models: Compartment Models in Individual and Population Analysis
Pharmacodynamic Models: Logarithmic Concentration–Effect Model
Pharmacodynamic Models: Direct Effect Model and Indirect Response Model
Pharmacodynamic Models: Link Model and Systems Pharmacodynamic Model
Toxicity Testing in Animals

