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Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology
08:01

Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology

Published on: March 22, 2012

Invasive aspergillosis: an important risk factor on the short- and long-term survival of acute myeloid leukemia (AML)

M Michallet1, T Bénet, M Sobh

  • 1Hematology Department, Edouard Herriot Hospital, Hospices Civils de Lyon, 5 Place d'Arsonval, 69437, Lyon Cedex 03, France. mauricette.michallet@chu-lyon.fr

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
|September 13, 2011
PubMed

Insights

Invasive aspergillosis (IA) significantly increases mortality risk in acute myeloid leukemia (AML) patients undergoing induction chemotherapy. This fungal infection drastically reduces survival rates, regardless of treatment response.

Area of Science:

  • Hematology
  • Infectious Diseases
  • Oncology

Background:

  • Invasive aspergillosis (IA) poses a significant threat during induction chemotherapy for acute myeloid leukemia (AML).
  • IA can complicate treatment strategies and negatively impact patient prognosis.

Purpose of the Study:

  • To investigate how IA development affects AML therapeutic strategies.
  • To evaluate the short- and long-term survival impact of IA in AML patients.

Main Methods:

  • Retrospective analysis of newly diagnosed AML patients (2004-2007).
  • Cox proportional hazards model used to assess the impact of IA diagnosis and treatment response on survival.
  • 262 patients analyzed; 58 cases of IA observed.

Main Results:

  • Two-year survival was 54% for AML remission patients versus 5% for chemotherapy failure patients (p < 0.001).
  • Two-year survival was 14% for patients with IA versus 32% for patients without IA (p = 0.01).
  • Multivariate analysis revealed IA significantly increased death risk in both remission (HR=1.66) and failure (HR=6.43) groups.

Conclusions:

  • IA is associated with a substantially increased risk of death in AML patients.
  • The negative survival impact of IA persists irrespective of remission or chemotherapy failure status.

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