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Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...
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Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
Imaging Studies III: Computed Tomography01:27

Imaging Studies III: Computed Tomography

DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...

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Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (FDG-PET/CT)
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Functional testicular evaluation using PET/CT with 18F-fluorodeoxyglucose.

Lawrence Oliver Dierickx1, Eric Huyghe, Daniela Nogueira

  • 1Service of Nuclear Medicine, Institut Claudius Regaud, Toulouse, France. dierickx.lawrence@claudiusregaud.fr

European Journal of Nuclear Medicine and Molecular Imaging
|September 13, 2011
PubMed
Summary
This summary is machine-generated.

Positron emission tomography/computed tomography (PET/CT) with (18)F-FDG can assess testicular function. This pilot study found correlations between FDG uptake, testicular volume, and sperm parameters, suggesting its potential in male infertility diagnosis.

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Area of Science:

  • Nuclear medicine
  • Andrology
  • Radiomics

Background:

  • Positron emission tomography/computed tomography (PET/CT) with fluorine-18-fluorodeoxyglucose ((18)F-FDG) is established in oncology, cardiology, and neurology.
  • The clinical significance of non-tumoral testicular uptake of (18)F-FDG is not well understood.
  • Functional testicular imaging holds potential for diagnosing and prognosing male infertility.

Purpose of the Study:

  • To evaluate the andrological value of (18)F-FDG PET/CT in assessing testicular function.
  • To correlate (18)F-FDG PET/CT parameters with sperm parameters in men without testicular pathology.

Main Methods:

  • Retrospective analysis of (18)F-FDG PET/CT scans in 20 cancer patients prior to chemotherapy.
  • Measured parameters included mean standardized uptake value (SUVmean) and functional testicular volume (FV).
  • Statistical analysis employed Spearman's rank correlation and Mann-Whitney tests.

Main Results:

  • Significant correlations were observed between SUVmean, FV, and sperm count, concentration, and motility (p < 0.05).
  • The difference in SUVmean between testes inversely correlated with sperm concentration (p = 0.036).
  • Normospermic and oligospermic men showed significant differences in SUVmean, FV, and inter-testicular SUVmean difference (p < 0.05).

Conclusions:

  • This is the first study to report on the andrological value of (18)F-FDG PET/CT for non-tumoral testicular function.
  • The findings suggest a significant correlation between (18)F-FDG uptake, testicular FV, and key sperm parameters.
  • (18)F-FDG PET/CT may emerge as a valuable tool for assisted reproductive technologies and other andrological/urological applications.